(+/-)15-HEDE (CAS 92693-04-4)
(+/-)15-HEDE (CAS:
92693-04-4) has molecular formula C20H36O3 and molecular weight 324.5 g/mol. This compound has been the subject of numerous scientific investigations due to its structural features and practical utility in synthetic chemistry and industrial processes. View product details →
Product Background
This comprehensive research profile examines the scientific literature surrounding (+/-)15-HEDE.
Key Research Findings
- Of the 112 screened LMs, 26 were increased between 2 to >25-fold in BALF with HDM treatment .
- We demonstrated previously that the 20-HETE-dependent inhibition of NO production is mediated through inhibitor of κB kinase , suggesting a cross-talk between 20-HETE-mediated endo
- However, several analogues in which the 5,8-diene had been reduced were also found to inhibit the enzyme.
- Superficial psoriatic scale was shown to contain biologically active amounts of leukotriene B4 and monohydroxy-eicosatetraenoic acid -like material as determined by assay for chemo
Detailed Literature Analysis
Below are the top-ranked research papers for (+/-)15-HEDE, presented with bibliographic details and scientific abstracts.
Synthetic Chemistry
1. Androgen-dependent hypertension is mediated by 20-hydroxy-5,8,11,14-eicosatetraenoic acid-induced vascular dysfunction: role of inhibitor of kappaB Kinase.
Increased vascular synthesis of 20-hydroxy-5,8,11,14-eicosatetraenoic acid (20-HETE) is associated with increased vascular contraction, endothelial dysfunction, and endothelial activation; all are believed to account for 20-HETE prohypertensive properties. We demonstrated previously that the 20-HETE-dependent inhibition of NO production is mediated
🔑 Key Finding: We demonstrated previously that the 20-HETE-dependent inhibition of NO production is mediated
Biological & Pharmacological Studies
2. Prominent release of lipoxygenase generated mediators in a murine house dust mite-induced asthma model.
The profile of activation of lipid mediator (LM) pathways in asthmatic airway inflammation remains unclear. This experimental study quantified metabolite levels of ω3-, ω6- and ω9-derived polyunsaturated fatty acids in bronchoalveolar lavage fluid (BALF) after 4-weeks of repeated house dust mite (HDM) exposure in a murine (C57BL/6) asthma model. Th
3. Structural requirements for the inhibition of 5-lipoxygenase by 15-hydroxyeicosa-5,8,11,13-tetraenoic acid analogues.
The structural requirements for inhibition of RBL-1 (rat basophilic leukemia) 5-lipoxygenase by 15-hydroxyeicosa-5,8,11,13-tetraenoic acid (15-HETE, 1) were studied by systematic chemical modifications of the molecule at the hydroxyl and carboxyl groups, the double bonds, and the carboxylate and omega side chains. The most potent inhibitors were an
4. The identification of hydroxy fatty acids in psoriatic skin.
Psoriasis is a common chronic inflammatory and proliferative skin disease characterised by epidermal neutrophil infiltration which may be induced by chemotactic substances in the involved epidermis. Superficial psoriatic scale was shown to contain biologically active amounts of leukotriene B4 and monohydroxy-eicosatetraenoic acid (HETE)-like materi
5. 15-hydroxy eicosadienoic acid is an exacerbating factor for nasal congestion in mice.
Allergic rhinitis (AR) is one of the most common allergic inflammatory diseases worldwide. In AR, increased blood flow and vascular permeability in nasal mucosa cause rhinorrhea and nasal congestion. We investigated the role of an 11Z,14Z-eicosadienoic acid-derived metabolite, 15-hydroxy-11Z,13Z-eicosadienoic acid (15-HEDE), in functional changes i
6. Analysis of human colostrum reveals differential co-occurrence networks of metabolites, microbiota and cytokines in maternal obesity.
Breastmilk is essential for neonatal development, particularly in seeding the gut microbiota and modulating the immune system. This proof-of-concept study explores the systemic nature of colostrum and the influence of maternal obesity on co-occurrences of colostrum bioactives. Using 16S-rRNA sequencing, untargeted metabolomics, and cytokine quantif
Conclusion
The research literature on (+/-)15-HEDE demonstrates sustained scientific interest, with publications continuing through 0. The compound serves as an important building block in synthetic chemistry and has been explored for various applications. Researchers and industrial users can view detailed specifications or submit an inquiry for pricing and availability.
Data Sources: PubMed/MEDLINE, CrossRef. 6 papers analyzed. Last updated: 2026-05-25. This article is automatically generated from peer-reviewed research data.