(2,3-Dimethoxy-benzyl)-phenethyl-amine — Research Review
CAS: 101582-36-9. View product page
Research Overview
This review analyzes 3 peer-reviewed publications on (2,3-Dimethoxy-benzyl)-phenethyl-amine, spanning synthetic methodology, structural characterization, and applied research.
Key Findings
- The compounds were screened against three drug resistant malarial strains and were found to exhibit sub-micromolar activity across all three strains .
- Such compounds have been shown to inhibit the IKKβ subunit, preventing phosphorylation of the cytoplasmic IκB inhibitory complex.
- It shows that the phosphoryl group is the strongest nitrogen lone pair electron localizing group as compared with the corresponding sulfonyl and acyl derivatives.
Synthetic Studies
1. The synthesis, antimalarial activity and CoMFA analysis of novel aminoalkylated quercetin analogs.
Bioorganic & medicinal chemistry letters ()
A series of novel aminoalkylated quercetin analogs, prepared via the Mannich reaction of various primary and secondary amines with formaldehyde, were tested for antimalarial activity. The compounds were screened against three drug resistant malarial
2. Antitumor properties of novel sesquiterpene lactone analogs as NFκB inhibitors that bind to the IKKβ ubiquitin-like domain (ULD).
European journal of medicinal chemistry ()
Melampomagnolide B (MMB, 3) is a parthenolide (PTL, 1) based sesquiterpene lactone that has been used as a template for the synthesis of a plethora of lead anticancer agents owing to its reactive C-10 primary hydroxyl group. Such compounds have been
3. X-ray photoelectron spectra study on the derivatives of N-beta-phenethyl amine and N-beta-phenethyl glycine.
Scientia Sinica. Series B, Chemical, biological, agricultural, medical & earth sciences ()
The X-ray photoelectron spectra of sixteen derivatives of N-beta-phenethyl amine and N-beta-phenethyl glycine have been studied. The effect of different structures on N1s binding energy and that of their Pauling's atomic charge density on the nitroge
Sources: PubMed, CrossRef. 3 papers. 2026-05-25