4-Bromoanisole (CAS 104-92-7) is one of the most versatile aryl halide building blocks in pharmaceutical synthesis — a liquid at room temperature, dual-functional (bromine + methoxy), and available from five major global suppliers at competitive prices. The global bromoanisole market was valued at $127 million in 2025 and is projected to reach $206 million by 2034, growing at 5.5% CAGR — driven by expanding pharmaceutical R&D pipelines and increasing demand for high-purity (≥99%) building blocks [003].
What Are the Physical Properties of 4-Bromoanisole?
4-Bromoanisole (1-bromo-4-methoxybenzene, p-bromoanisole) is a clear, light yellow liquid at room temperature — a rare and valuable characteristic among aryl bromides, most of which are crystalline solids [001].
| Property | Value |
|---|---|
| CAS Number | 104-92-7 |
| Molecular Formula | C₇H₇BrO |
| Molecular Weight | 187.03 g/mol |
| XLogP | 2.8 |
| Melting Point | 9–10 °C |
| Appearance | Clear light yellow liquid |
| SMILES | COC1=CC=C(C=C1)Br |
The liquid physical state simplifies handling, dispensing, and solution preparation — a practical advantage in both discovery and process chemistry workflows.
What Makes 4-Bromoanisole a Dual-Functional Building Block?
The compound's synthetic value derives from its two functional groups working in concert [002]:
- Bromine atom — the primary reactive handle for oxidative addition to Pd(0), enabling Suzuki-Miyaura, Heck, Sonogashira, and Ullmann couplings
- Methoxy group — electron-donating character modulates coupling electronics; can be cleaved to reveal a phenol, opening access to an entirely different chemical space
This dual functionality makes 4-bromoanisole significantly more versatile than simple aryl bromides like bromobenzene.
Which Suppliers Offer 4-Bromoanisole?
Five major global suppliers compete in the bromoanisole market [003]:
| Supplier | Market Share | Catalog Number |
|---|---|---|
| Alfa Aesar (Thermo Fisher) | 28% | — |
| TCI Chemicals | 18.3% | B0547 |
| Sigma-Aldrich (MilliporeSigma) | 18% | B56501 |
| Acros Organics | 14% | — |
| Apollo Scientific | ~12% | — |
Sigma-Aldrich offers ≥99.0% purity under catalog B56501 [002]. This competitive landscape — where no single supplier dominates — benefits buyers through price pressure and guaranteed availability.
This product is available through CoreyChem under CAS 104-92-7 [004].
What Are the Key Pharmaceutical Applications?
Pharmaceutical intermediates represent the largest application segment for bromoanisole, accounting for the dominant share of market revenue [003]. Specific uses include:
- Suzuki-Miyaura coupling to construct biaryl pharmaceutical scaffolds (kinase inhibitors, GPCR modulators)
- Copper-catalyzed Ullmann couplings for diaryl ether pharmacophores (vancomycin-class antibiotics)
- API synthesis across oncology, cardiovascular, and CNS therapeutic areas
Agrochemical intermediates represent the second-largest market, driven by demand for novel herbicides, insecticides, and fungicides requiring biaryl or aryl ether motifs [003].
What Is the Regional Market Breakdown?
Asia-Pacific dominates with ~45% market share and the fastest growth rate (6.5–7.0% CAGR), led by pharmaceutical and agrochemical manufacturing expansion in China and India [003]:
| Region | Share | Growth |
|---|---|---|
| Asia-Pacific | ~45% | 6.5–7.0% |
| North America | ~20% | 4.5–5.0% |
| Europe | ~20% | 4.0–4.5% |
| Middle East/Africa | ~8% | 5.0–5.5% |
| South America | ~7% | 5.0–5.5% |
Frequently Asked Questions
Q: What is 4-bromoanisole used for?
It serves as an electrophilic coupling partner in palladium-catalyzed cross-coupling (Suzuki, Heck, Sonogashira, Ullmann) for pharmaceutical and agrochemical intermediate synthesis. Its dual bromo-methoxy functionality enables diverse product architectures [002].
Q: Is 4-bromoanisole a liquid or solid?
A clear, light yellow liquid at room temperature (mp 9–10 °C) — one of the few liquid aryl bromides routinely used in synthesis [001].
Q: What is the difference between 4-bromoanisole and 4-iodoanisole?
4-Iodoanisole (CAS 696-62-8) is more reactive but more expensive and light-sensitive. 4-Bromoanisole offers a better balance of reactivity, cost, and stability for most applications.
Q: How large is the bromoanisole market?
$127 million in 2025, projected to reach $206 million by 2034 at 5.5% CAGR, driven by pharmaceutical R&D demand [003].
Q: Where can I buy 4-bromoanisole?
Available from Alfa Aesar, TCI Chemicals, Sigma-Aldrich (B56501), Acros Organics, and Apollo Scientific. Also available through CoreyChem under CAS 104-92-7 [002][004].
Q: What purity grades are available?
Standard research grade is ≥99.0% (Sigma-Aldrich). GMP-grade (≥99.5%) may be available for pharmaceutical applications through custom order [002].
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Source Through CoreyChem
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References & Sources
https://pubchem.ncbi.nlm.nih.gov/compound/7730
https://www.sigmaaldrich.com/US/en/search/104-92-7
https://www.datainsightsreports.com/reports/global-bromoanisole-market-67246
