(-)-C-IDU (CAS 120963-45-3)
(-)-C-IDU (CAS:
120963-45-3) has molecular formula C10H13IN2O4 and molecular weight 352.13 g/mol. This compound has been the subject of numerous scientific investigations due to its structural features and practical utility in synthetic chemistry and industrial processes. View product details →
Product Background
This comprehensive research profile examines the scientific literature surrounding (-)-C-IDU.
Key Research Findings
- Our discovery that Herpes virus thymidine kinase and cellular deoxycytidine kinase lack enantioselectivity, being able to phosphorylate both D- and L-enantiomers of the substrate,
- These estimates suggest that HCV prevalence in NYC is higher than previously indicated from household surveys
- The inhibition of HSV-1 TK by BVDU, IDU, -C-BVDU, and -C-IDU was purely competitive with regard to the natural substrate , whereas -C-BVDU, -C-IDU, -C-BVDU, and C-IDU showed a line
Detailed Literature Analysis
Below are the top-ranked research papers for (-)-C-IDU, presented with bibliographic details and scientific abstracts.
Synthetic Chemistry
1. A Bayesian Evidence Synthesis Approach to Estimate Disease Prevalence in Hard-To-Reach Populations: Hepatitis C in New York City
Existing methods to estimate the prevalence of chronic hepatitis C (HCV) in New York City (NYC) are limited in scope and fail to assess hard-to-reach subpopulations with highest risk such as injecting drug users (IDUs). To address these limitations, we employ a Bayesian multi-parameter evidence synthesis model to systematically combine multiple sou
2. A Bayesian Evidence Synthesis Approach to Estimate Disease Prevalence in Hard-To-Reach Populations: Hepatitis C in New York City
Existing methods to estimate the prevalence of chronic hepatitis C (HCV) in New York City (NYC) are limited in scope and fail to assess hard-to-reach subpopulations with highest risk such as injecting drug users (IDUs). To address these limitations, we employ a Bayesian multi-parameter evidence synthesis model to systematically combine multiple sou
3. Carbocyclic 5-iodo-2'-deoxyuridine (C-IDU) and carbocyclic (E)-5-(2-bromovinyl)-2'-deoxyuridine (C-BVDU) as unique examples of chiral molecules where the two enantiomeric forms are biologically active
The (+)- and (-)-enantiomers of the carbocyclic analogues of (E)-5-(2-bromovinyl)-2'-deoxyuridine (C-BVDU) and 5-iodo-2'-deoxyuridine (C-IDU) were synthesized by separate routes. Both the (+)- and (-)-enantiomers of C-BVDU and C-IDU were markedly inhibitory to herpes simplex virus type 1 (HSV-1) replication. (+)-C-BVDU and (+)-C-IDU were as inhibit
4. A Discrete Simulation Optimization Approach Towards Calibration of an Agent-based Simulation Model of Hepatitis C Virus Transmission
This study demonstrates the implementation of the stochastic ruler discrete simulation optimization method for calibrating an agent-based model (ABM) developed to simulate hepatitis C virus (HCV) transmission. The ABM simulates HCV transmission between agents interacting in multiple environments relevant for HCV transmission in the Indian context.
5. A Discrete Simulation Optimization Approach Towards Calibration of an Agent-based Simulation Model of Hepatitis C Virus Transmission
This study demonstrates the implementation of the stochastic ruler discrete simulation optimization method for calibrating an agent-based model (ABM) developed to simulate hepatitis C virus (HCV) transmission. The ABM simulates HCV transmission between agents interacting in multiple environments relevant for HCV transmission in the Indian context.
Biological & Pharmacological Studies
6. Relaxed enantioselectivity of human mitochondrial thymidine kinase and chemotherapeutic uses of L-nucleoside analogues.
Our discovery that Herpes virus thymidine kinase (TK) and cellular deoxycytidine kinase lack enantioselectivity, being able to phosphorylate both D- and L-enantiomers of the substrate, suggested the use of unnatural L-nucleoside analogues as antiviral drugs (Herpes, hepatitis and immunodeficiency viruses). Several L-nucleoside analogues have displa
Other Research
7. Implementing an information-theoretically secure Byzantine agreement with quantum signed message solution
Byzantine agreement (BA) enables all honest nodes in a decentralized network to reach consensus. In the era of emerging quantum technologies, classical cryptography-based BA protocols face inherent security vulnerabilities. By leveraging the information-theoretic security of keys generated by quantum processing, such as quantum key distribution (QK
8. Implementing an information-theoretically secure Byzantine agreement with quantum signed message solution
Byzantine agreement (BA) enables all honest nodes in a decentralized network to reach consensus. In the era of emerging quantum technologies, classical cryptography-based BA protocols face inherent security vulnerabilities. By leveraging the information-theoretic security of keys generated by quantum processing, such as quantum key distribution (QK
Conclusion
The research literature on (-)-C-IDU demonstrates sustained scientific interest, with publications continuing through 0. The compound serves as an important building block in synthetic chemistry and has been explored for various applications. Researchers and industrial users can view detailed specifications or submit an inquiry for pricing and availability.
Data Sources: PubMed/MEDLINE, CrossRef. 8 papers analyzed. Last updated: 2026-05-25. This article is automatically generated from peer-reviewed research data.