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What Is HATU?
HATU (CAS 148893-10-1) is a peptide coupling reagent with the molecular formula C10H15F6N6OP and molecular weight 380.23 g/mol. [001]
Physical and Chemical Properties
| Property | Value | Source |
|---|---|---|
| CAS Number | 148893-10-1 | |
| Molecular Formula | C10H15F6N6OP | |
| Molecular Weight | 380.23 g/mol |
How It Works
HATU activates carboxylic acids by forming an OAt active ester, releasing tetramethylurea. The pyridine nitrogen in HOAt provides neighboring-group assistance that accelerates aminolysis relative to oxazolone formation.
Key Applications
- Solid-Phase Peptide Synthesis: HATU is the reagent of choice for Fmoc-based SPPS, activating carboxylic acids with minimal racemization. Standard protocol: 3.9 equiv HATU, 4.0 equiv Fmoc-AA-OH, 6-8 equiv DIPEA in DMF, 30-45 min coupling. [004]
- Difficult Couplings: The HOAt leaving group's pyridine nitrogen provides neighboring-group assistance, accelerating aminolysis and suppressing oxazolone-mediated racemization. [001]
- GLP-1 Analog Manufacturing: The growth of semaglutide and related incretin therapeutics has driven demand for HATU at manufacturing scale for 30+ amino acid peptide APIs. [004]
Handling and Storage
- GHS Hazard: H315 (Skin irritation), H319 (Eye irritation), H335 (Respiratory irritation)
- Storage: Store at -20°C under inert atmosphere (argon or nitrogen) in tightly closed amber containers. HATU is hygroscopic.
- PPE: Wear nitrile gloves, safety goggles, and lab coat. [002]
Always consult the Safety Data Sheet (SDS) from your supplier before handling. SDS documents are lot-specific — different purity grades and formulations may have different hazard classifications. For bulk handling, consult your institution's chemical hygiene plan and perform a job hazard analysis (JHA) before beginning work. Emergency procedures: in case of skin contact, wash immediately with soap and water for at least 15 minutes. For eye contact, rinse cautiously with water for several minutes and remove contact lenses if present. If inhaled, move to fresh air. Seek medical attention if symptoms persist.
Regulatory & Compliance
Chemical Inventories: HATU (CAS 148893-10-1) is listed on major chemical inventories including the TSCA (Toxic Substances Control Act) inventory in the United States, EINECS (European Inventory of Existing Commercial Chemical Substances) in the EU, and similar inventories in Japan (ENCS), China (IECSC), Korea (KECL), and Australia (AICS). The specific regulatory status of CAS 148893-10-1 should be verified with the appropriate national authority before importing into any jurisdiction, as inventory listing status can change with regulatory updates and new chemical assessments.
GHS Classification: Refer to the Handling and Storage section above for the Globally Harmonized System hazard classification. The GHS classification is harmonized across most jurisdictions, but specific national implementations (EU CLP Regulation, US OSHA HazCom 2012, China GB 30000 series) may have additional requirements.
Transport Information: Verify the proper shipping name, UN number, hazard class, and packing group with your supplier before shipping. Transport regulations (IATA/ICAO for air, IMDG for sea, ADR/RID for road/rail in Europe, 49 CFR for US ground) may impose quantity limits, packaging requirements, and documentation obligations. Some compounds may be classified as dangerous goods requiring specialized handling and certified packaging.
Export Control: HATU is a standard research and industrial chemical. However, always verify that no specific export control regulations apply to your destination country. Certain chemical categories (precursors, dual-use chemicals) may require export licenses under the Chemical Weapons Convention (CWC), Australia Group guidelines, or national export control laws. Contact your local trade compliance office for the most current regulatory guidance.
[004] [002]
Frequently Asked Questions
What is the CAS number of HATU?
The CAS Registry Number is 148893-10-1. Always specify the CAS number when ordering to ensure correct compound identification regardless of naming conventions. [001]
What is the molecular weight of HATU?
The molecular weight is 380.23 g/mol based on the molecular formula C10H15F6N6OP. Use this value to calculate molar equivalents, determine reaction stoichiometry, and prepare solutions of known concentration. [001]
What is HATU used for?
HATU is used for: Solid-Phase Peptide Synthesis (HATU is the reagent of choice for Fmoc-based SPPS, activating carboxylic acids w...); Difficult Couplings (The HOAt leaving group's pyridine nitrogen provides neighboring-group assistance...); GLP-1 Analog Manufacturing (The growth of semaglutide and related incretin therapeutics has driven demand fo...). For detailed protocols, see the Key Applications section above. [002]
How should HATU be stored?
Store at -20°C under inert atmosphere (argon or nitrogen) in tightly closed amber containers. HATU is hygroscopic.. Always consult the Safety Data Sheet (SDS) from your specific supplier for the most accurate storage recommendations. [002]
Where can I buy HATU?
HATU (CAS 148893-10-1) may be sourced through CoreyChem. For bulk pricing, custom packaging, and a certificate of analysis, submit an inquiry to our sales team with your CAS number, required quantity, and desired purity. [002]
Where to Buy
HATU (CAS 148893-10-1) is not currently listed in the CoreyChem catalog. Contact [email protected] for sourcing assistance. [003]
Our sourcing team can assist with procurement from qualified manufacturers worldwide. Please provide the CAS number, required quantity, and desired purity when submitting your inquiry for the fastest response.
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References & Sources
https://www.tcichemicals.com/US/en/search/?text=148893-10-1
https://www.benchchem.com/search?q=148893-10-1
https://scholar.google.com/scholar?q=HATU
