(+-)-Philanthotoxin-433 (CAS 123949-33-7)
(+-)-Philanthotoxin-433 (CAS:
123949-33-7) has molecular formula C23H41N5O3 and molecular weight 435.6 g/mol. This compound has been the subject of numerous scientific investigations due to its structural features and practical utility in synthetic chemistry and industrial processes. View product details →
Product Background
This comprehensive research profile examines the scientific literature surrounding (+-)-Philanthotoxin-433.
Key Research Findings
- Interestingly, SPARC has been shown to be upregulated in CNS injury and disease.
- However, here we demonstrate that different receptor perturbations that similarly reduce synaptic transmission result in different responses at the Drosophila neuromuscular junctio
- These data demonstrate that the involvement of CP-AMPARs in LTP is critically determined by the timing of the induction trigger and is associated specifically with the PKA-dependen
- Previous work showed a 22-fold selectivity of PhTX-12 over PhTX-343 for embryonic muscle-type nicotinic acetylcholine receptors in TE671 cells.
Detailed Literature Analysis
Below are the top-ranked research papers for (+-)-Philanthotoxin-433, presented with bibliographic details and scientific abstracts.
Synthetic Chemistry
1. New Analogs of Polyamine Toxins from Spiders and Wasps: Liquid Phase Fragment Synthesis and Evaluation of Antiproliferative Activity.
Polyamine toxins (PATs) are conjugates of polyamines (PAs) with lipophilic carboxylic acids, which have been recently shown to present antiproliferative activity. Ten analogs of the spider PATs
🔑 Key Finding: Polyamine toxins are conjugates of polyamines with lipophilic carboxylic acids, which have been recently shown to present antiproliferative activity.
Biological & Pharmacological Studies
2. SPARC and GluA1-Containing AMPA Receptors Promote Neuronal Health Following CNS Injury.
The proper formation and maintenance of functional synapses in the central nervous system (CNS) requires communication between neurons and astrocytes and the ability of astrocytes to release neuromodulatory molecules. Previously, we described a novel role for the astrocyte-secreted matricellular protein SPARC (Secreted Protein, Acidic and Rich in C
3. Distinct molecular pathways govern presynaptic homeostatic plasticity.
Presynaptic homeostatic plasticity (PHP) stabilizes synaptic transmission by counteracting impaired neurotransmitter receptor function through neurotransmitter release potentiation. PHP is thought to be triggered by impaired receptor function and to involve a stereotypic signaling pathway. However, here we demonstrate that different receptor pertur
4. Calcium-Permeable AMPA Receptors Mediate the Induction of the Protein Kinase A-Dependent Component of Long-Term Potentiation in the Hippocampus.
Two forms of NMDA receptor (NMDAR)-dependent long-term potentiation (LTP) at hippocampal CA1 synapses can be distinguished based on their sensitivity to inhibitors of protein kinase A (PKA). The PKA-dependent form requires multiple episodes of high-frequency stimulation (HFS) or theta burst stimuli (TBS) with a spacing between episodes in the order
5. Block of nicotinic acetylcholine receptors by philanthotoxins is strongly dependent on their subunit composition.
Philanthotoxin-433 (PhTX-433) is an active component of the venom from the Egyptian digger wasp, Philanthus triangulum. PhTX-433 inhibits several excitatory ligand-gated ion channels, and to improve selectivity two synthetic analogues, PhTX-343 and PhTX-12, were developed. Previous work showed a 22-fold selectivity of PhTX-12 over PhTX-343 for embr
Conclusion
The research literature on (+-)-Philanthotoxin-433 demonstrates sustained scientific interest, with publications continuing through 0. The compound serves as an important building block in synthetic chemistry and has been explored for various applications. Researchers and industrial users can view detailed specifications or submit an inquiry for pricing and availability.
Data Sources: PubMed/MEDLINE, CrossRef. 5 papers analyzed. Last updated: 2026-05-25. This article is automatically generated from peer-reviewed research data.