Glibenclamide
TL;DR: Glibenclamide (CAS 10238-21-8) is a chemical compound with molecular formula C23H28ClN3O5S and molecular weight 493.14383 g/mol, supplied by CoreyChem (Career Henan Chemical Co., Ltd.) with ISO-certified quality and global shipping.
5-chloro-N-[2-[4-(cyclohexylcarbamoylsulfamoyl)phenyl]ethyl]-2-methoxybenzamide
Also Known As: Glibenclamide, glyburide, Glybenclamide, Glynase, Micronase
Application Areas
Top 5 of 19 IPC patent classification(s) from the SureChEMBL global patent database.
Technical Specifications
| Molecular Formula | C23H28ClN3O5S |
| Molecular Weight | 493.14383 g/mol |
| XLogP | 4.8 |
| Topological Polar Surface Area (TPSA) | 122.0 Ų |
| Hydrogen Bond Donors | 3 |
| Hydrogen Bond Acceptors | 5 |
| Rotatable Bonds | 8 |
| Exact Mass | 493.14383 Da |
| Heavy Atoms | 33 |
| Complexity | 746.0 |
| Melting Point | 169 |
| Solubility | 2.06e-03 g/L |
| SMILES | COC1=C(C=C(C=C1)Cl)C(=O)NCCC2=CC=C(C=C2)S(=O)(=O)NC(=O)NC3CCCCC3 |
| InChIKey | ZNNLBTZKUZBEKO-UHFFFAOYSA-N |
Chemical Property Profile of Glibenclamide
Property Insights of Glibenclamide
The XLogP value of 4.8 indicates that Glibenclamide is lipophilic (fat-soluble), which may influence its absorption, distribution, and formulation strategy. The TPSA of 122.0 Ų falls within the moderate polarity range, balancing permeability and solubility for Glibenclamide. Following Lipinski's Rule of Five, Glibenclamide has 3 hydrogen bond donor(s) and 5 hydrogen bond acceptor(s), all within the drug-like range, suggesting favorable oral bioavailability potential.
Frequently Asked Questions
What is the CAS number of Glibenclamide?
The CAS number of Glibenclamide is 10238-21-8.
What is the molecular formula of Glibenclamide?
The molecular formula of Glibenclamide is C23H28ClN3O5S.
What is the molecular weight of Glibenclamide?
The molecular weight of Glibenclamide is 493.14383 g/mol.
Where can I buy Glibenclamide?
You can request a quote for Glibenclamide directly from CoreyChem. Contact us or email [email protected] for pricing and availability.
Does CoreyChem offer custom synthesis for Glibenclamide?
Yes, CoreyChem provides custom synthesis services for Glibenclamide and related compounds. Contact us with your specific requirements including quantity, purity, and timeline.