Dolastatin 11
TL;DR: Dolastatin 11 (CAS 111517-68-1) is a chemical compound with molecular formula C50H80N8O12 and molecular weight 984.5896 g/mol, supplied by CoreyChem (Career Henan Chemical Co., Ltd.) with ISO-certified quality and global shipping.
(2S,8S,14S,17S,20S,25S,28R,29S)-2-[(2S)-butan-2-yl]-28-ethyl-17-[(4-methoxyphenyl)methyl]-7,13,16,20,22,22,25,29-octamethyl-8-(2-methylpropyl)-14-propan-2-yl-1-oxa-4,7,10,13,16,19,24,27-octazacyclotriacontane-3,6,9,12,15,18,21,23,26,30-decone
Also Known As: Dolastatin 11, ANTINEOPLASTIC-D606195, From marine animal Dolabella auricularia, NCI60_004658, B720389K031
Application Areas
Top 5 of 2 IPC patent classification(s) from the SureChEMBL global patent database.
Technical Specifications
| Molecular Formula | C50H80N8O12 |
| Molecular Weight | 984.5896 g/mol |
| XLogP | 5.1 |
| Topological Polar Surface Area (TPSA) | 259.0 Ų |
| Hydrogen Bond Donors | 5 |
| Hydrogen Bond Acceptors | 12 |
| Rotatable Bonds | 9 |
| Exact Mass | 984.5896 Da |
| Heavy Atoms | 70 |
| Complexity | 1870.0 |
| SMILES | CC[C@@H]1[C@@H](C(=O)O[C@H](C(=O)NCC(=O)N([C@H](C(=O)NCC(=O)N([C@H](C(=O)N([C@H](C(=O)N[C@H](C(=O)C(C(=O)N[C@H](C(=O)N1)C)(C)C)C)CC2=CC=C(C=C2)OC)C)C(C)C)C)CC(C)C)C)[C@@H](C)CC)C |
| InChIKey | XOSLDLHSPLPVME-FKLVWXFWSA-N |
Chemical Property Profile of Dolastatin 11
Property Insights of Dolastatin 11
The XLogP value of 5.1 indicates that Dolastatin 11 is lipophilic (fat-soluble), which may influence its absorption, distribution, and formulation strategy. The TPSA of 259.0 Ų indicates high polarity, suggesting Dolastatin 11 may have limited membrane permeability but good aqueous solubility. Following Lipinski's Rule of Five, Dolastatin 11 has 5 hydrogen bond donor(s) and 12 hydrogen bond acceptor(s), which may warrant consideration for formulation optimization.
Frequently Asked Questions
What is the CAS number of Dolastatin 11?
The CAS number of Dolastatin 11 is 111517-68-1.
What is the molecular formula of Dolastatin 11?
The molecular formula of Dolastatin 11 is C50H80N8O12.
What is the molecular weight of Dolastatin 11?
The molecular weight of Dolastatin 11 is 984.5896 g/mol.
Where can I buy Dolastatin 11?
You can request a quote for Dolastatin 11 directly from CoreyChem. Contact us or email [email protected] for pricing and availability.
Does CoreyChem offer custom synthesis for Dolastatin 11?
Yes, CoreyChem provides custom synthesis services for Dolastatin 11 and related compounds. Contact us with your specific requirements including quantity, purity, and timeline.