Losartan
TL;DR: Losartan (CAS 114798-26-4) is a chemical compound with molecular formula C22H23ClN6O and molecular weight 422.1622 g/mol, supplied by CoreyChem (Career Henan Chemical Co., Ltd.) with ISO-certified quality and global shipping.
[2-butyl-5-chloro-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol
Also Known As: losartan, allisartan, Lortaan, Hyzaar, Angizaar
Application Areas
Top 5 of 15 IPC patent classification(s) from the SureChEMBL global patent database.
Technical Specifications
| Molecular Formula | C22H23ClN6O |
| Molecular Weight | 422.1622 g/mol |
| XLogP | 4.3 |
| Topological Polar Surface Area (TPSA) | 92.5 Ų |
| Hydrogen Bond Donors | 2 |
| Hydrogen Bond Acceptors | 5 |
| Rotatable Bonds | 8 |
| Exact Mass | 422.1622 Da |
| Heavy Atoms | 30 |
| Complexity | 520.0 |
| Melting Point | 178-184 |
| Boiling Point | 682 |
| Solubility | <1mg/mL |
| SMILES | CCCCC1=NC(=C(N1CC2=CC=C(C=C2)C3=CC=CC=C3C4=NNN=N4)CO)Cl |
| InChIKey | PSIFNNKUMBGKDQ-UHFFFAOYSA-N |
Chemical Property Profile of Losartan
Property Insights of Losartan
The XLogP value of 4.3 indicates that Losartan is lipophilic (fat-soluble), which may influence its absorption, distribution, and formulation strategy. The TPSA of 92.5 Ų falls within the moderate polarity range, balancing permeability and solubility for Losartan. Following Lipinski's Rule of Five, Losartan has 2 hydrogen bond donor(s) and 5 hydrogen bond acceptor(s), all within the drug-like range, suggesting favorable oral bioavailability potential.
Frequently Asked Questions
What is the CAS number of Losartan?
The CAS number of Losartan is 114798-26-4.
What is the molecular formula of Losartan?
The molecular formula of Losartan is C22H23ClN6O.
What is the molecular weight of Losartan?
The molecular weight of Losartan is 422.1622 g/mol.
Where can I buy Losartan?
You can request a quote for Losartan directly from CoreyChem. Contact us or email [email protected] for pricing and availability.
Does CoreyChem offer custom synthesis for Losartan?
Yes, CoreyChem provides custom synthesis services for Losartan and related compounds. Contact us with your specific requirements including quantity, purity, and timeline.