Tolazamide
TL;DR: Tolazamide (CAS 1156-19-0) is a chemical compound with molecular formula C14H21N3O3S and molecular weight 311.13037 g/mol, supplied by CoreyChem (Career Henan Chemical Co., Ltd.) with ISO-certified quality and global shipping.
1-(azepan-1-yl)-3-(4-methylphenyl)sulfonylurea
Also Known As: tolazamide, Tolinase, Norglycin, Tolanase, Tolazolamide
Application Areas
Top 5 of 15 IPC patent classification(s) from the SureChEMBL global patent database.
Technical Specifications
| Molecular Formula | C14H21N3O3S |
| Molecular Weight | 311.13037 g/mol |
| XLogP | 1.5 |
| Topological Polar Surface Area (TPSA) | 86.9 Ų |
| Hydrogen Bond Donors | 2 |
| Hydrogen Bond Acceptors | 4 |
| Rotatable Bonds | 3 |
| Exact Mass | 311.13037 Da |
| Heavy Atoms | 21 |
| Complexity | 431.0 |
| Melting Point | 322 to 336 °F (with decomposition) (NTP, 1992) |
| Solubility | less than 1 mg/mL at 77 °F (NTP, 1992) |
| SMILES | CC1=CC=C(C=C1)S(=O)(=O)NC(=O)NN2CCCCCC2 |
| InChIKey | OUDSBRTVNLOZBN-UHFFFAOYSA-N |
Product Description
Applications: Tolazamide is used in pharmaceutical synthesis routes and API production, as well as heterocycle construction in medicinal chemistry and agrochemical discovery. It commonly serves as a versatile building block for organic synthesis. Available from CoreyChem as both catalog item and custom-synthesis project (mg to ton scale), with full analytical documentation (COA, MSDS, HPLC, NMR, MS).
Tolazamide is a pharmaceutical intermediate identified by CAS number 1156-19-0 and the molecular formula C14H21N3O3S and a molecular weight of 311.13 g/mol. Physically, the compound has a solubility: less than 1 mg/mL at 77 °F (NTP, 1992). Synonyms include tolazamide and Tolinase.
Custom synthesis and full analytical documentation (COA/MSDS) are available from CoreyChem. Request a quotation with your required quantity and purity for current lead time and pricing.
Chemical Property Profile of Tolazamide
Property Insights of Tolazamide
The XLogP value of 1.5 suggests moderate lipophilicity, balancing water solubility and membrane permeability for Tolazamide. The TPSA of 86.9 Ų falls within the moderate polarity range, balancing permeability and solubility for Tolazamide. Following Lipinski's Rule of Five, Tolazamide has 2 hydrogen bond donor(s) and 4 hydrogen bond acceptor(s), all within the drug-like range, suggesting favorable oral bioavailability potential.
Frequently Asked Questions
What is the CAS number of Tolazamide?
The CAS number of Tolazamide is 1156-19-0.
What is the molecular formula of Tolazamide?
The molecular formula of Tolazamide is C14H21N3O3S.
What is the molecular weight of Tolazamide?
The molecular weight of Tolazamide is 311.13037 g/mol.
What are the applications of Tolazamide?
Tolazamide is used in pharmaceutical synthesis routes and API production, as well as heterocycle construction in medicinal chemistry and agrochemical discovery. It commonly serves as a versatile building block for organic synthesis. Available from CoreyChem as both catalog item and...
Where can I buy Tolazamide?
You can request a quote for Tolazamide directly from CoreyChem. Contact us or email [email protected] for pricing and availability.
Does CoreyChem offer custom synthesis for Tolazamide?
Yes, CoreyChem provides custom synthesis services for Tolazamide and related compounds. Contact us with your specific requirements including quantity, purity, and timeline.