(-)-Nebivolol
TL;DR: (-)-Nebivolol (CAS 118457-14-0) is a chemical compound with molecular formula C22H25F2NO4 and molecular weight 405.17517 g/mol, supplied by CoreyChem (Career Henan Chemical Co., Ltd.) with ISO-certified quality and global shipping.
(1S)-1-[(2R)-6-fluoro-3,4-dihydro-2H-chromen-2-yl]-2-[[(2S)-2-[(2S)-6-fluoro-3,4-dihydro-2H-chromen-2-yl]-2-hydroxyethyl]amino]ethanol
Also Known As: Nebivolol, Levonebivolol, (-)-Nebivolol, l-nebivolol, levonebivololum
Technical Specifications
| Molecular Formula | C22H25F2NO4 |
| Molecular Weight | 405.17517 g/mol |
| XLogP | 3.0 |
| Topological Polar Surface Area (TPSA) | 71.0 Ų |
| Hydrogen Bond Donors | 3 |
| Hydrogen Bond Acceptors | 7 |
| Rotatable Bonds | 6 |
| Exact Mass | 405.17517 Da |
| Heavy Atoms | 29 |
| Complexity | 483.0 |
| SMILES | C1CC2=C(C=CC(=C2)F)O[C@H]1[C@H](CNC[C@@H]([C@@H]3CCC4=C(O3)C=CC(=C4)F)O)O |
| InChIKey | KOHIRBRYDXPAMZ-YHDSQAASSA-N |
Chemical Property Profile of (-)-Nebivolol
Property Insights of (-)-Nebivolol
The XLogP value of 3.0 indicates that (-)-Nebivolol is lipophilic (fat-soluble), which may influence its absorption, distribution, and formulation strategy. The TPSA of 71.0 Ų falls within the moderate polarity range, balancing permeability and solubility for (-)-Nebivolol. Following Lipinski's Rule of Five, (-)-Nebivolol has 3 hydrogen bond donor(s) and 7 hydrogen bond acceptor(s), all within the drug-like range, suggesting favorable oral bioavailability potential.
Frequently Asked Questions
What is the CAS number of (-)-Nebivolol?
The CAS number of (-)-Nebivolol is 118457-14-0.
What is the molecular formula of (-)-Nebivolol?
The molecular formula of (-)-Nebivolol is C22H25F2NO4.
What is the molecular weight of (-)-Nebivolol?
The molecular weight of (-)-Nebivolol is 405.17517 g/mol.
Where can I buy (-)-Nebivolol?
You can request a quote for (-)-Nebivolol directly from CoreyChem. Contact us or email [email protected] for pricing and availability.
Does CoreyChem offer custom synthesis for (-)-Nebivolol?
Yes, CoreyChem provides custom synthesis services for (-)-Nebivolol and related compounds. Contact us with your specific requirements including quantity, purity, and timeline.