O-Desmethylnaftopidil
TL;DR: O-Desmethylnaftopidil (CAS 1333493-12-1) is a chemical compound with molecular formula C23H26N2O3 and molecular weight 378.19434 g/mol, supplied by CoreyChem (Career Henan Chemical Co., Ltd.) with ISO-certified quality and global shipping.
2-[4-(2-hydroxy-3-naphthalen-1-yloxypropyl)piperazin-1-yl]phenol
Also Known As: O-Desmethylnaftopidil, O-Demethylnaftopidil, O-desmethyl-naftopidil, 2-(4-(2-HYDROXY-3-(NAPHTHALEN-1-YLOXY)PROPYL)PIPERAZIN-1-YL)PHENOL, 2-[4-(2-hydroxy-3-naphthalen-1-yloxypropyl)piperazin-1-yl]phenol
Application Areas
Top 5 of 2 IPC patent classification(s) from the SureChEMBL global patent database.
Technical Specifications
| Molecular Formula | C23H26N2O3 |
| Molecular Weight | 378.19434 g/mol |
| XLogP | 3.8 |
| Topological Polar Surface Area (TPSA) | 56.2 Ų |
| Hydrogen Bond Donors | 2 |
| Hydrogen Bond Acceptors | 5 |
| Rotatable Bonds | 6 |
| Exact Mass | 378.19434 Da |
| Heavy Atoms | 28 |
| Complexity | 469.0 |
| SMILES | C1CN(CCN1CC(COC2=CC=CC3=CC=CC=C32)O)C4=CC=CC=C4O |
| InChIKey | SRBVIBLTYWRHJQ-UHFFFAOYSA-N |
Chemical Property Profile of O-Desmethylnaftopidil
Property Insights of O-Desmethylnaftopidil
The XLogP value of 3.8 indicates that O-Desmethylnaftopidil is lipophilic (fat-soluble), which may influence its absorption, distribution, and formulation strategy. With a topological polar surface area (TPSA) of 56.2 Ų, O-Desmethylnaftopidil exhibits relatively low polarity, potentially indicating favorable cell membrane permeability. Following Lipinski's Rule of Five, O-Desmethylnaftopidil has 2 hydrogen bond donor(s) and 5 hydrogen bond acceptor(s), all within the drug-like range, suggesting favorable oral bioavailability potential.
Frequently Asked Questions
What is the CAS number of O-Desmethylnaftopidil?
The CAS number of O-Desmethylnaftopidil is 1333493-12-1.
What is the molecular formula of O-Desmethylnaftopidil?
The molecular formula of O-Desmethylnaftopidil is C23H26N2O3.
What is the molecular weight of O-Desmethylnaftopidil?
The molecular weight of O-Desmethylnaftopidil is 378.19434 g/mol.
Where can I buy O-Desmethylnaftopidil?
You can request a quote for O-Desmethylnaftopidil directly from CoreyChem. Contact us or email [email protected] for pricing and availability.
Does CoreyChem offer custom synthesis for O-Desmethylnaftopidil?
Yes, CoreyChem provides custom synthesis services for O-Desmethylnaftopidil and related compounds. Contact us with your specific requirements including quantity, purity, and timeline.