N5-(3,5-Difluorophenyl)-2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxamide
TL;DR: N5-(3,5-Difluorophenyl)-2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxamide (CAS 154934-69-7) is a chemical compound with molecular formula C12H5ClF5N3O and molecular weight 337.00412 g/mol, supplied by CoreyChem (Career Henan Chemical Co., Ltd.) with ISO-certified quality and global shipping.
2-chloro-N-(3,5-difluorophenyl)-4-(trifluoromethyl)pyrimidine-5-carboxamide
Also Known As: N5-(3,5-Difluorophenyl)-2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxamide, 2-chloro-N-(3,5-difluorophenyl)-4-(trifluoromethyl)pyrimidine-5-carboxamide, 2-Chloro-N-(3,5-difluorophenyl)-4-(trifluoromethyl)-5-pyrimidinecarboxamide, C12H5ClF5N3O
Technical Specifications
| Molecular Formula | C12H5ClF5N3O |
| Molecular Weight | 337.00412 g/mol |
| XLogP | 3.1 |
| Topological Polar Surface Area (TPSA) | 54.9 Ų |
| Hydrogen Bond Donors | 1 |
| Hydrogen Bond Acceptors | 8 |
| Rotatable Bonds | 2 |
| Exact Mass | 337.00412 Da |
| Heavy Atoms | 22 |
| Complexity | 401.0 |
| SMILES | C1=C(C=C(C=C1F)F)NC(=O)C2=CN=C(N=C2C(F)(F)F)Cl |
| InChIKey | ZJUCPOQDJIMIMO-UHFFFAOYSA-N |
Chemical Property Profile of N5-(3,5-Difluorophenyl)-2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxamide
Property Insights of N5-(3,5-Difluorophenyl)-2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxamide
The XLogP value of 3.1 indicates that N5-(3,5-Difluorophenyl)-2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxamide is lipophilic (fat-soluble), which may influence its absorption, distribution, and formulation strategy. With a topological polar surface area (TPSA) of 54.9 Ų, N5-(3,5-Difluorophenyl)-2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxamide exhibits relatively low polarity, potentially indicating favorable cell membrane permeability. Following Lipinski's Rule of Five, N5-(3,5-Difluorophenyl)-2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxamide has 1 hydrogen bond donor(s) and 8 hydrogen bond acceptor(s), all within the drug-like range, suggesting favorable oral bioavailability potential.
Frequently Asked Questions
What is the CAS number of N5-(3,5-Difluorophenyl)-2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxamide?
The CAS number of N5-(3,5-Difluorophenyl)-2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxamide is 154934-69-7.
What is the molecular formula of N5-(3,5-Difluorophenyl)-2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxamide?
The molecular formula of N5-(3,5-Difluorophenyl)-2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxamide is C12H5ClF5N3O.
What is the molecular weight of N5-(3,5-Difluorophenyl)-2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxamide?
The molecular weight of N5-(3,5-Difluorophenyl)-2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxamide is 337.00412 g/mol.
Where can I buy N5-(3,5-Difluorophenyl)-2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxamide?
You can request a quote for N5-(3,5-Difluorophenyl)-2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxamide directly from CoreyChem. Contact us or email [email protected] for pricing and availability.
Does CoreyChem offer custom synthesis for N5-(3,5-Difluorophenyl)-2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxamide?
Yes, CoreyChem provides custom synthesis services for N5-(3,5-Difluorophenyl)-2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxamide and related compounds. Contact us with your specific requirements including quantity, purity, and timeline.