Metolazone
TL;DR: Metolazone (CAS 17560-51-9) is a chemical compound with molecular formula C16H16ClN3O3S and molecular weight 365.0601 g/mol, supplied by CoreyChem (Career Henan Chemical Co., Ltd.) with ISO-certified quality and global shipping.
7-chloro-2-methyl-3-(2-methylphenyl)-4-oxo-1,2-dihydroquinazoline-6-sulfonamide
Also Known As: metolazone, Zaroxolyn, Diulo, Mykrox, Oldren
Application Areas
Top 5 of 14 IPC patent classification(s) from the SureChEMBL global patent database.
Technical Specifications
| Molecular Formula | C16H16ClN3O3S |
| Molecular Weight | 365.0601 g/mol |
| XLogP | 4.1 |
| Topological Polar Surface Area (TPSA) | 101.0 Ų |
| Hydrogen Bond Donors | 2 |
| Hydrogen Bond Acceptors | 5 |
| Rotatable Bonds | 2 |
| Exact Mass | 365.0601 Da |
| Heavy Atoms | 24 |
| Complexity | 594.0 |
| Melting Point | 256 |
| Solubility | 60.3 |
| SMILES | CC1NC2=CC(=C(C=C2C(=O)N1C3=CC=CC=C3C)S(=O)(=O)N)Cl |
| InChIKey | AQCHWTWZEMGIFD-UHFFFAOYSA-N |
Product Description
Applications: Metolazone is used in pharmaceutical synthesis routes and API production, as well as heterocycle construction in medicinal chemistry and agrochemical discovery. It commonly serves as a versatile building block for organic synthesis. Available from CoreyChem as both catalog item and custom-synthesis project (mg to ton scale), with full analytical documentation (COA, MSDS, HPLC, NMR, MS).
Metolazone is a pharmaceutical intermediate identified by CAS number 17560-51-9 and the molecular formula C16H16ClN3O3S and a molecular weight of 365.06 g/mol. Physically, the compound has a solubility: 60.3. Synonyms include metolazone and Zaroxolyn.
Custom synthesis and full analytical documentation (COA/MSDS) are available from CoreyChem. Request a quotation with your required quantity and purity for current lead time and pricing.
Chemical Property Profile of Metolazone
Property Insights of Metolazone
The XLogP value of 4.1 indicates that Metolazone is lipophilic (fat-soluble), which may influence its absorption, distribution, and formulation strategy. The TPSA of 101.0 Ų falls within the moderate polarity range, balancing permeability and solubility for Metolazone. Following Lipinski's Rule of Five, Metolazone has 2 hydrogen bond donor(s) and 5 hydrogen bond acceptor(s), all within the drug-like range, suggesting favorable oral bioavailability potential.
Frequently Asked Questions
What is the CAS number of Metolazone?
The CAS number of Metolazone is 17560-51-9.
What is the molecular formula of Metolazone?
The molecular formula of Metolazone is C16H16ClN3O3S.
What is the molecular weight of Metolazone?
The molecular weight of Metolazone is 365.0601 g/mol.
What are the applications of Metolazone?
Metolazone is used in pharmaceutical synthesis routes and API production, as well as heterocycle construction in medicinal chemistry and agrochemical discovery. It commonly serves as a versatile building block for organic synthesis. Available from CoreyChem as both catalog item and...
Where can I buy Metolazone?
You can request a quote for Metolazone directly from CoreyChem. Contact us or email [email protected] for pricing and availability.
Does CoreyChem offer custom synthesis for Metolazone?
Yes, CoreyChem provides custom synthesis services for Metolazone and related compounds. Contact us with your specific requirements including quantity, purity, and timeline.