Lofepramine
TL;DR: Lofepramine (CAS 23047-25-8) is a chemical compound with molecular formula C26H27ClN2O and molecular weight 418.18118 g/mol, supplied by CoreyChem (Career Henan Chemical Co., Ltd.) with ISO-certified quality and global shipping.
1-(4-chlorophenyl)-2-[3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)propyl-methylamino]ethanone
Also Known As: LOFEPRAMINE, Lopramine, Amplit, Lofepramina, Lofepraminum
Application Areas
Top 5 of 13 IPC patent classification(s) from the SureChEMBL global patent database.
Technical Specifications
| Molecular Formula | C26H27ClN2O |
| Molecular Weight | 418.18118 g/mol |
| XLogP | 6.8 |
| Topological Polar Surface Area (TPSA) | 23.6 Ų |
| Hydrogen Bond Donors | 0 |
| Hydrogen Bond Acceptors | 3 |
| Rotatable Bonds | 7 |
| Exact Mass | 418.18118 Da |
| Heavy Atoms | 30 |
| Complexity | 523.0 |
| Melting Point | 104-406 °C |
| Vapor Pressure | 1.5X10-9 mm Hg @ 25 °C /Estimated/ |
| Solubility | In water, 1.4X10-2 mg/L @ 25 °C /Estimated/ |
| SMILES | CN(CCCN1C2=CC=CC=C2CCC3=CC=CC=C31)CC(=O)C4=CC=C(C=C4)Cl |
| InChIKey | SAPNXPWPAUFAJU-UHFFFAOYSA-N |
Product Description
Applications: Lofepramine is used in pharmaceutical synthesis routes and API production, as well as heterocycle construction in medicinal chemistry and agrochemical discovery. It commonly serves as a versatile building block for organic synthesis. CoreyChem supplies Lofepramine (CAS 23047-25-8) with custom synthesis available from milligram to multi-kilogram scale, supported by COA, MSDS, and HPLC/NMR/MS documentation.
Lofepramine (CAS 23047-25-8) is a pharmaceutical intermediate with the molecular formula C26H27ClN2O and a molecular weight of 418.18 g/mol. Key physical properties include a solubility: In water, 1.4X10-2 mg/L @ 25 °C /Estimated/. It is also known as LOFEPRAMINE and Lopramine.
Custom synthesis and full analytical documentation (COA/MSDS) are available from CoreyChem. Request a quotation with your required quantity and purity for current lead time and pricing.
Chemical Property Profile of Lofepramine
Property Insights of Lofepramine
The XLogP value of 6.8 indicates that Lofepramine is lipophilic (fat-soluble), which may influence its absorption, distribution, and formulation strategy. With a topological polar surface area (TPSA) of 23.6 Ų, Lofepramine exhibits relatively low polarity, potentially indicating favorable cell membrane permeability. Following Lipinski's Rule of Five, Lofepramine has 0 hydrogen bond donor(s) and 3 hydrogen bond acceptor(s), which may warrant consideration for formulation optimization.
Frequently Asked Questions
What is the CAS number of Lofepramine?
The CAS number of Lofepramine is 23047-25-8.
What is the molecular formula of Lofepramine?
The molecular formula of Lofepramine is C26H27ClN2O.
What is the molecular weight of Lofepramine?
The molecular weight of Lofepramine is 418.18118 g/mol.
What are the applications of Lofepramine?
Lofepramine is used in pharmaceutical synthesis routes and API production, as well as heterocycle construction in medicinal chemistry and agrochemical discovery. It commonly serves as a versatile building block for organic synthesis. CoreyChem supplies Lofepramine (CAS 23047-25-8) with custom...
Where can I buy Lofepramine?
You can request a quote for Lofepramine directly from CoreyChem. Contact us or email [email protected] for pricing and availability.
Does CoreyChem offer custom synthesis for Lofepramine?
Yes, CoreyChem provides custom synthesis services for Lofepramine and related compounds. Contact us with your specific requirements including quantity, purity, and timeline.