Polythiazide
TL;DR: Polythiazide (CAS 346-18-9) is a chemical compound with molecular formula C11H13ClF3N3O4S3 and molecular weight 438.9709 g/mol, supplied by CoreyChem (Career Henan Chemical Co., Ltd.) with ISO-certified quality and global shipping.
6-chloro-2-methyl-1,1-dioxo-3-(2,2,2-trifluoroethylsulfanylmethyl)-3,4-dihydro-1λ6,2,4-benzothiadiazine-7-sulfonamide
Also Known As: polythiazide, Renese, Drenusil, Nephril, Politiazida
Application Areas
Top 5 of 13 IPC patent classification(s) from the SureChEMBL global patent database.
Technical Specifications
| Molecular Formula | C11H13ClF3N3O4S3 |
| Molecular Weight | 438.9709 g/mol |
| XLogP | 2.6 |
| Topological Polar Surface Area (TPSA) | 152.0 Ų |
| Hydrogen Bond Donors | 2 |
| Hydrogen Bond Acceptors | 11 |
| Rotatable Bonds | 4 |
| Exact Mass | 438.9709 Da |
| Heavy Atoms | 25 |
| Complexity | 692.0 |
| Melting Point | 396.5 °F (NTP, 1992) |
| Solubility | less than 1 mg/mL at 68 °F (NTP, 1992) |
| SMILES | CN1C(NC2=CC(=C(C=C2S1(=O)=O)S(=O)(=O)N)Cl)CSCC(F)(F)F |
| InChIKey | CYLWJCABXYDINA-UHFFFAOYSA-N |
Product Description
Applications: Polythiazide is used in pharmaceutical synthesis routes and API production, as well as heterocycle construction in medicinal chemistry and agrochemical discovery. It commonly serves as a versatile building block for organic synthesis. Available from CoreyChem as both catalog item and custom-synthesis project (mg to ton scale), with full analytical documentation (COA, MSDS, HPLC, NMR, MS).
Polythiazide (CAS 346-18-9) is a pharmaceutical intermediate with the molecular formula C11H13ClF3N3O4S3 and a molecular weight of 438.97 g/mol. Key physical properties include a solubility: less than 1 mg/mL at 68 °F (NTP, 1992). Synonyms include polythiazide and Renese.
Custom synthesis and full analytical documentation (COA/MSDS) are available from CoreyChem. Request a quotation with your required quantity and purity for current lead time and pricing.
Chemical Property Profile of Polythiazide
Property Insights of Polythiazide
The XLogP value of 2.6 suggests moderate lipophilicity, balancing water solubility and membrane permeability for Polythiazide. The TPSA of 152.0 Ų indicates high polarity, suggesting Polythiazide may have limited membrane permeability but good aqueous solubility. Following Lipinski's Rule of Five, Polythiazide has 2 hydrogen bond donor(s) and 11 hydrogen bond acceptor(s), which may warrant consideration for formulation optimization.
Frequently Asked Questions
What is the CAS number of Polythiazide?
The CAS number of Polythiazide is 346-18-9.
What is the molecular formula of Polythiazide?
The molecular formula of Polythiazide is C11H13ClF3N3O4S3.
What is the molecular weight of Polythiazide?
The molecular weight of Polythiazide is 438.9709 g/mol.
What are the applications of Polythiazide?
Polythiazide is used in pharmaceutical synthesis routes and API production, as well as heterocycle construction in medicinal chemistry and agrochemical discovery. It commonly serves as a versatile building block for organic synthesis. Available from CoreyChem as both catalog item and...
Where can I buy Polythiazide?
You can request a quote for Polythiazide directly from CoreyChem. Contact us or email [email protected] for pricing and availability.
Does CoreyChem offer custom synthesis for Polythiazide?
Yes, CoreyChem provides custom synthesis services for Polythiazide and related compounds. Contact us with your specific requirements including quantity, purity, and timeline.