(-)-Epipodophyllotoxin

(5S,5aR,8aR,9R)-5-hydroxy-9-(3,4,5-trimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[5,6-f][1,3]benzodioxol-8-one

Also Known As: Epipodophyllotoxin|(-)-epipodophyllotoxin|Etopside|podophyllotoxin|epi-Podophyllotoxin|VP16|HY-N7654|TN7041|137513-EP2272827A1|137513-EP2292088A1|5-19-10-00665 (Beilstein Handbook Reference)|(5R,5aR,8aR,9S)-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-5,8,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one|(5S,5aR,8aR,9R)-5-hydroxy-9-(3,4,5-trimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[5,6-f][1,3]benzodioxol-8-one|(5R)-5beta-(3,4,5-Trimethoxyphenyl)-7alpha-(hydroxymethyl)-8alpha-hydroxy-5,6,7,8-tetrahydronaphtho[2,3-d]-1,3-dioxole-6beta-carboxylic acid 6,7-lactone|Podophyllotoxin, (5R-(5 alpha,5a beta,8a alpha,9 beta))-Isomer|Furo(3',4':6,7)naphtho(2,3-d)-1,3-dioxol-6(5aH)-one, 5,8,8a,9-tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-, (5R,5aR,8aR,9S)-|Furo(3',4':6,7)naphtho(2,3-d)-1,3-dioxol-6(5aH)-one, 5,8,8a,9-tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-, (5R-(5-alpha,5a-beta,8a-alpha,9-beta))-|(10R,11R,15R,16S)-16-hydroxy-10-(3,4,5-trimethoxyphenyl)-4,6,13-trioxatetracyclo[7.7.0.0^{3,7}.0^{11,15}]hexadeca-1(9),2,7-trien-12-one|(10R,11R,15R,16S)-16-hydroxy-10-(3,4,5-trimethoxyphenyl)-4,6,13-trioxatetracyclo[7.7.0.03,7.011,15]hexadeca-1(9),2,7-trien-12-one|(10R,11R,15R,16S)-16-hydroxy-10-(3,4,5-trimethoxyphenyl)-4,6,13-trioxatetracyclo[7.7.0.03,7.011,15]hexadeca-1,3(7),8-trien-12-one|(5R)-5,5aalpha,8abeta,9-Tetrahydro-9alpha-hydroxy-5beta-(3,4,5-trimethoxyphenyl)furo[3 ,4 :6,7]naphtho[2,3-d]-1,3-dioxole-6(8H)-one|(5R)-5,8,8abeta,9-Tetrahydro-9alpha-hydroxy-5beta-(3,4,5-trimethoxyphenyl)furo[3 ,4 :6,7]naphtho[2,3-d]-1,3-dioxole-(5aalphaH)-one|(5R)-5|A-(3,4,5-Trimethoxyphenyl)-7|A-(hydroxymethyl)-8|A-hydroxy-5,6,7,8-tetrahydronaphtho[2,3-d]-1,3-dioxole-6|A-carboxylic acid 6,7-lactone|(5R)-5beta-(3,4,5-Trimethoxyphenyl)-9-hydroxy-5,5aalpha,8abeta,9beta-tetrahydrofuro[3 ,4 :6,7]naphtho[2,3-d]-1,3-dioxole-6(8H)-one

Molecular Formula	C22H22O8
Molecular Weight	414.13147 g/mol
LogP	2.41
Topological Polar Surface Area	92.68 Ų
Hydrogen Bond Donors	1
Hydrogen Bond Acceptors	8
Rotatable Bonds	4
Exact Mass	414.13147
Heavy Atoms	30
Complexity	991.4

Chemical Identifiers

CAS Number	4375-07-9
SMILES	COC1=CC(=CC(=C1OC)OC)[C@H]2[C@@H]3[C@H](COC3=O)[C@@H](C4=CC5=C(C=C24)OCO5)O