5-Fluorouracil
TL;DR: 5-Fluorouracil (CAS 51-21-8) is a chemical compound with molecular formula C4H3FN2O2 and molecular weight 130.01785 g/mol, supplied by CoreyChem (Career Henan Chemical Co., Ltd.) with ISO-certified quality and global shipping.
5-fluoro-1H-pyrimidine-2,4-dione
Also Known As: 5-Fluorouracil, fluorouracil, Efudex, Fluoroplex, Adrucil
Application Areas
Top 5 of 22 IPC patent classification(s) from the SureChEMBL global patent database.
Technical Specifications
| Molecular Formula | C4H3FN2O2 |
| Molecular Weight | 130.01785 g/mol |
| XLogP | -0.9 |
| Topological Polar Surface Area (TPSA) | 58.2 Ų |
| Hydrogen Bond Donors | 2 |
| Hydrogen Bond Acceptors | 3 |
| Rotatable Bonds | 0 |
| Exact Mass | 130.01785 Da |
| Heavy Atoms | 9 |
| Complexity | 199.0 |
| Melting Point | Decomposes at 540-541 °F (EPA, 1998) |
| Boiling Point | Decomposes at 282-283 °C; sublimes (0.1 mm): 190-200 °C |
| Vapor Pressure | 0.00001 [mm Hg] @25 °C |
| Solubility | less than 1 mg/mL at 66 °F (NTP, 1992) |
| SMILES | C1=C(C(=O)NC(=O)N1)F |
| InChIKey | GHASVSINZRGABV-UHFFFAOYSA-N |
Product Description
Applications: 5-Fluorouracil is used in pharmaceutical synthesis routes and API production, as well as biotechnology workflows and life-science research. It commonly serves as a versatile building block for organic synthesis. CoreyChem supplies 5-Fluorouracil (CAS 51-21-8) with custom synthesis available from milligram to multi-kilogram scale, supported by COA, MSDS, and HPLC/NMR/MS documentation.
A pharmaceutical intermediate supplied by CoreyChem, 5-Fluorouracil (CAS 51-21-8) has the molecular formula C4H3FN2O2 and a molecular weight of 130.02 g/mol. Reported properties include a solubility: less than 1 mg/mL at 66 °F (NTP, 1992). It is also known as 5-Fluorouracil and fluorouracil.
Custom synthesis and full analytical documentation (COA/MSDS) are available from CoreyChem. Request a quotation with your required quantity and purity for current lead time and pricing.
Chemical Property Profile of 5-Fluorouracil
Property Insights of 5-Fluorouracil
The XLogP value of -0.9 indicates that 5-Fluorouracil is hydrophilic (water-soluble), making it suitable for aqueous formulations and biological assay applications. With a topological polar surface area (TPSA) of 58.2 Ų, 5-Fluorouracil exhibits relatively low polarity, potentially indicating favorable cell membrane permeability. Following Lipinski's Rule of Five, 5-Fluorouracil has 2 hydrogen bond donor(s) and 3 hydrogen bond acceptor(s), all within the drug-like range, suggesting favorable oral bioavailability potential.
Frequently Asked Questions
What is the CAS number of 5-Fluorouracil?
The CAS number of 5-Fluorouracil is 51-21-8.
What is the molecular formula of 5-Fluorouracil?
The molecular formula of 5-Fluorouracil is C4H3FN2O2.
What is the molecular weight of 5-Fluorouracil?
The molecular weight of 5-Fluorouracil is 130.01785 g/mol.
What are the applications of 5-Fluorouracil?
5-Fluorouracil is used in pharmaceutical synthesis routes and API production, as well as biotechnology workflows and life-science research. It commonly serves as a versatile building block for organic synthesis. CoreyChem supplies 5-Fluorouracil (CAS 51-21-8) with custom synthesis available from...
Where can I buy 5-Fluorouracil?
You can request a quote for 5-Fluorouracil directly from CoreyChem. Contact us or email [email protected] for pricing and availability.
Does CoreyChem offer custom synthesis for 5-Fluorouracil?
Yes, CoreyChem provides custom synthesis services for 5-Fluorouracil and related compounds. Contact us with your specific requirements including quantity, purity, and timeline.