Loperamide
TL;DR: Loperamide (CAS 53179-11-6) is a chemical compound with molecular formula C29H33ClN2O2 and molecular weight 476.22305 g/mol, supplied by CoreyChem (Career Henan Chemical Co., Ltd.) with ISO-certified quality and global shipping.
4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-N,N-dimethyl-2,2-diphenylbutanamide
Also Known As: loperamide, Loperamida, Ioperamide, Loperamidum, Imodium
Application Areas
Top 5 of 17 IPC patent classification(s) from the SureChEMBL global patent database.
Technical Specifications
| Molecular Formula | C29H33ClN2O2 |
| Molecular Weight | 476.22305 g/mol |
| XLogP | 5.0 |
| Topological Polar Surface Area (TPSA) | 43.8 Ų |
| Hydrogen Bond Donors | 1 |
| Hydrogen Bond Acceptors | 3 |
| Rotatable Bonds | 7 |
| Exact Mass | 476.22305 Da |
| Heavy Atoms | 34 |
| Complexity | 623.0 |
| Melting Point | 220-228 |
| SMILES | CN(C)C(=O)C(CCN1CCC(CC1)(C2=CC=C(C=C2)Cl)O)(C3=CC=CC=C3)C4=CC=CC=C4 |
| InChIKey | RDOIQAHITMMDAJ-UHFFFAOYSA-N |
Chemical Property Profile of Loperamide
Property Insights of Loperamide
The XLogP value of 5.0 indicates that Loperamide is lipophilic (fat-soluble), which may influence its absorption, distribution, and formulation strategy. With a topological polar surface area (TPSA) of 43.8 Ų, Loperamide exhibits relatively low polarity, potentially indicating favorable cell membrane permeability. Following Lipinski's Rule of Five, Loperamide has 1 hydrogen bond donor(s) and 3 hydrogen bond acceptor(s), all within the drug-like range, suggesting favorable oral bioavailability potential.
Frequently Asked Questions
What is the CAS number of Loperamide?
The CAS number of Loperamide is 53179-11-6.
What is the molecular formula of Loperamide?
The molecular formula of Loperamide is C29H33ClN2O2.
What is the molecular weight of Loperamide?
The molecular weight of Loperamide is 476.22305 g/mol.
Where can I buy Loperamide?
You can request a quote for Loperamide directly from CoreyChem. Contact us or email [email protected] for pricing and availability.
Does CoreyChem offer custom synthesis for Loperamide?
Yes, CoreyChem provides custom synthesis services for Loperamide and related compounds. Contact us with your specific requirements including quantity, purity, and timeline.