Amitriptyline Hydrochloride
TL;DR: Amitriptyline Hydrochloride (CAS 549-18-8) is a chemical compound with molecular formula C20H24ClN and molecular weight 313.15973 g/mol, supplied by CoreyChem (Career Henan Chemical Co., Ltd.) with ISO-certified quality and global shipping.
N,N-dimethyl-3-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaenylidene)propan-1-amine;hydrochloride
Also Known As: Amitriptyline hydrochloride, Amitriptyline HCl, Annoyltin, Tryptizol, Syneudon
Application Areas
Top 5 of 13 IPC patent classification(s) from the SureChEMBL global patent database.
Technical Specifications
| Molecular Formula | C20H24ClN |
| Molecular Weight | 313.15973 g/mol |
| XLogP | 4.59 |
| Topological Polar Surface Area (TPSA) | 3.2 Ų |
| Hydrogen Bond Donors | 1 |
| Hydrogen Bond Acceptors | 1 |
| Rotatable Bonds | 3 |
| Exact Mass | 313.15973 Da |
| Heavy Atoms | 22 |
| Complexity | 331.0 |
| Solubility | >47.1 [ug/mL] (The mean of the results at pH 7.4) |
| SMILES | CN(C)CCC=C1C2=CC=CC=C2CCC3=CC=CC=C31.Cl |
| InChIKey | KFYRPLNVJVHZGT-UHFFFAOYSA-N |
Product Description
Applications: Amitriptyline Hydrochloride is used in pharmaceutical synthesis routes and API production, as well as heterocycle construction in medicinal chemistry and agrochemical discovery. It commonly serves as a versatile building block for organic synthesis. Available from CoreyChem as both catalog item and custom-synthesis project (mg to ton scale), with full analytical documentation (COA, MSDS, HPLC, NMR, MS).
A pharmaceutical intermediate supplied by CoreyChem, Amitriptyline Hydrochloride (CAS 549-18-8) has the molecular formula C20H24ClN and a molecular weight of 313.16 g/mol. Reported properties include a solubility: >47.1 [ug/mL] (The mean of the results at pH 7.4). Synonyms include Amitriptyline hydrochloride and Amitriptyline HCl.
Custom synthesis and full analytical documentation (COA/MSDS) are available from CoreyChem. Request a quotation with your required quantity and purity for current lead time and pricing.
Chemical Property Profile of Amitriptyline Hydrochloride
Property Insights of Amitriptyline Hydrochloride
The XLogP value of 4.59 indicates that Amitriptyline Hydrochloride is lipophilic (fat-soluble), which may influence its absorption, distribution, and formulation strategy. With a topological polar surface area (TPSA) of 3.2 Ų, Amitriptyline Hydrochloride exhibits relatively low polarity, potentially indicating favorable cell membrane permeability. Following Lipinski's Rule of Five, Amitriptyline Hydrochloride has 1 hydrogen bond donor(s) and 1 hydrogen bond acceptor(s), all within the drug-like range, suggesting favorable oral bioavailability potential.
Frequently Asked Questions
What is the CAS number of Amitriptyline Hydrochloride?
The CAS number of Amitriptyline Hydrochloride is 549-18-8.
What is the molecular formula of Amitriptyline Hydrochloride?
The molecular formula of Amitriptyline Hydrochloride is C20H24ClN.
What is the molecular weight of Amitriptyline Hydrochloride?
The molecular weight of Amitriptyline Hydrochloride is 313.15973 g/mol.
What are the applications of Amitriptyline Hydrochloride?
Amitriptyline Hydrochloride is used in pharmaceutical synthesis routes and API production, as well as heterocycle construction in medicinal chemistry and agrochemical discovery. It commonly serves as a versatile building block for organic synthesis. Available from CoreyChem as both catalog item...
Where can I buy Amitriptyline Hydrochloride?
You can request a quote for Amitriptyline Hydrochloride directly from CoreyChem. Contact us or email [email protected] for pricing and availability.
Does CoreyChem offer custom synthesis for Amitriptyline Hydrochloride?
Yes, CoreyChem provides custom synthesis services for Amitriptyline Hydrochloride and related compounds. Contact us with your specific requirements including quantity, purity, and timeline.