Meclizine
TL;DR: Meclizine (CAS 569-65-3) is a chemical compound with molecular formula C25H27ClN2 and molecular weight 390.18628 g/mol, supplied by CoreyChem (Career Henan Chemical Co., Ltd.) with ISO-certified quality and global shipping.
1-[(4-chlorophenyl)-phenylmethyl]-4-[(3-methylphenyl)methyl]piperazine
Also Known As: meclizine, Meclozine, Parachloramine, Vomisseis, Navicalm
Application Areas
Top 5 of 21 IPC patent classification(s) from the SureChEMBL global patent database.
Technical Specifications
| Molecular Formula | C25H27ClN2 |
| Molecular Weight | 390.18628 g/mol |
| XLogP | 5.8 |
| Topological Polar Surface Area (TPSA) | 6.5 Ų |
| Hydrogen Bond Donors | 0 |
| Hydrogen Bond Acceptors | 2 |
| Rotatable Bonds | 5 |
| Exact Mass | 390.18628 Da |
| Heavy Atoms | 28 |
| Complexity | 447.0 |
| Melting Point | 217-224 |
| Boiling Point | 230 °C @ 2 MM HG |
| Solubility | 0.1g/100mL |
| SMILES | CC1=CC(=CC=C1)CN2CCN(CC2)C(C3=CC=CC=C3)C4=CC=C(C=C4)Cl |
| InChIKey | OCJYIGYOJCODJL-UHFFFAOYSA-N |
Product Description
Applications: Meclizine is used in pharmaceutical synthesis routes and API production, as well as heterocycle construction in medicinal chemistry and agrochemical discovery. It commonly serves as a versatile building block for organic synthesis. Available from CoreyChem as both catalog item and custom-synthesis project (mg to ton scale), with full analytical documentation (COA, MSDS, HPLC, NMR, MS).
A pharmaceutical intermediate supplied by CoreyChem, Meclizine (CAS 569-65-3) has the molecular formula C25H27ClN2 and a molecular weight of 390.19 g/mol. Reported properties include a solubility: 0.1g/100mL. Synonyms include meclizine and Meclozine.
Custom synthesis and full analytical documentation (COA/MSDS) are available from CoreyChem. Request a quotation with your required quantity and purity for current lead time and pricing.
Chemical Property Profile of Meclizine
Property Insights of Meclizine
The XLogP value of 5.8 indicates that Meclizine is lipophilic (fat-soluble), which may influence its absorption, distribution, and formulation strategy. With a topological polar surface area (TPSA) of 6.5 Ų, Meclizine exhibits relatively low polarity, potentially indicating favorable cell membrane permeability. Following Lipinski's Rule of Five, Meclizine has 0 hydrogen bond donor(s) and 2 hydrogen bond acceptor(s), which may warrant consideration for formulation optimization.
Frequently Asked Questions
What is the CAS number of Meclizine?
The CAS number of Meclizine is 569-65-3.
What is the molecular formula of Meclizine?
The molecular formula of Meclizine is C25H27ClN2.
What is the molecular weight of Meclizine?
The molecular weight of Meclizine is 390.18628 g/mol.
What are the applications of Meclizine?
Meclizine is used in pharmaceutical synthesis routes and API production, as well as heterocycle construction in medicinal chemistry and agrochemical discovery. It commonly serves as a versatile building block for organic synthesis. Available from CoreyChem as both catalog item and...
Where can I buy Meclizine?
You can request a quote for Meclizine directly from CoreyChem. Contact us or email [email protected] for pricing and availability.
Does CoreyChem offer custom synthesis for Meclizine?
Yes, CoreyChem provides custom synthesis services for Meclizine and related compounds. Contact us with your specific requirements including quantity, purity, and timeline.