Promethazine Hydrochloride
TL;DR: Promethazine Hydrochloride (CAS 58-33-3) is a chemical compound with molecular formula C17H21ClN2S and molecular weight 320.1114 g/mol, supplied by CoreyChem (Career Henan Chemical Co., Ltd.) with ISO-certified quality and global shipping.
N,N-dimethyl-1-phenothiazin-10-ylpropan-2-amine;hydrochloride
Also Known As: PROMETHAZINE HYDROCHLORIDE, Promethazine Hcl, Phenergan, Remsed, Promethacon
Application Areas
Top 5 of 19 IPC patent classification(s) from the SureChEMBL global patent database.
Technical Specifications
| Molecular Formula | C17H21ClN2S |
| Molecular Weight | 320.1114 g/mol |
| XLogP | 4.66 |
| Topological Polar Surface Area (TPSA) | 31.8 Ų |
| Hydrogen Bond Donors | 1 |
| Hydrogen Bond Acceptors | 3 |
| Rotatable Bonds | 3 |
| Exact Mass | 320.1114 Da |
| Heavy Atoms | 21 |
| Complexity | 298.0 |
| Melting Point | 446 to 450 °F (decomposes) (NTP, 1992) |
| Solubility | greater than or equal to 100 mg/mL at 72 °F (NTP, 1992) |
| SMILES | CC(CN1C2=CC=CC=C2SC3=CC=CC=C31)N(C)C.Cl |
| InChIKey | XXPDBLUZJRXNNZ-UHFFFAOYSA-N |
Product Description
Applications: Promethazine Hydrochloride is used in pharmaceutical synthesis routes and API production, as well as heterocycle construction in medicinal chemistry and agrochemical discovery. It commonly serves as a versatile building block for organic synthesis. Available from CoreyChem as both catalog item and custom-synthesis project (mg to ton scale), with full analytical documentation (COA, MSDS, HPLC, NMR, MS).
Promethazine Hydrochloride (CAS 58-33-3) is a pharmaceutical intermediate with the molecular formula C17H21ClN2S and a molecular weight of 320.11 g/mol. Key physical properties include a solubility: greater than or equal to 100 mg/mL at 72 °F (NTP, 1992). Synonyms include PROMETHAZINE HYDROCHLORIDE and Promethazine Hcl.
Custom synthesis and full analytical documentation (COA/MSDS) are available from CoreyChem. Request a quotation with your required quantity and purity for current lead time and pricing.
Chemical Property Profile of Promethazine Hydrochloride
Property Insights of Promethazine Hydrochloride
The XLogP value of 4.66 indicates that Promethazine Hydrochloride is lipophilic (fat-soluble), which may influence its absorption, distribution, and formulation strategy. With a topological polar surface area (TPSA) of 31.8 Ų, Promethazine Hydrochloride exhibits relatively low polarity, potentially indicating favorable cell membrane permeability. Following Lipinski's Rule of Five, Promethazine Hydrochloride has 1 hydrogen bond donor(s) and 3 hydrogen bond acceptor(s), all within the drug-like range, suggesting favorable oral bioavailability potential.
Frequently Asked Questions
What is the CAS number of Promethazine Hydrochloride?
The CAS number of Promethazine Hydrochloride is 58-33-3.
What is the molecular formula of Promethazine Hydrochloride?
The molecular formula of Promethazine Hydrochloride is C17H21ClN2S.
What is the molecular weight of Promethazine Hydrochloride?
The molecular weight of Promethazine Hydrochloride is 320.1114 g/mol.
What are the applications of Promethazine Hydrochloride?
Promethazine Hydrochloride is used in pharmaceutical synthesis routes and API production, as well as heterocycle construction in medicinal chemistry and agrochemical discovery. It commonly serves as a versatile building block for organic synthesis. Available from CoreyChem as both catalog item...
Where can I buy Promethazine Hydrochloride?
You can request a quote for Promethazine Hydrochloride directly from CoreyChem. Contact us or email [email protected] for pricing and availability.
Does CoreyChem offer custom synthesis for Promethazine Hydrochloride?
Yes, CoreyChem provides custom synthesis services for Promethazine Hydrochloride and related compounds. Contact us with your specific requirements including quantity, purity, and timeline.