Hydrochlorothiazide
TL;DR: Hydrochlorothiazide (CAS 58-93-5) is a chemical compound with molecular formula C7H8ClN3O4S2 and molecular weight 296.96448 g/mol, supplied by CoreyChem (Career Henan Chemical Co., Ltd.) with ISO-certified quality and global shipping.
6-chloro-1,1-dioxo-3,4-dihydro-2H-1λ6,2,4-benzothiadiazine-7-sulfonamide
Also Known As: hydrochlorothiazide, Esidrix, Hypothiazide, Vetidrex, Hidrotiazida
Application Areas
Top 5 of 19 IPC patent classification(s) from the SureChEMBL global patent database.
Technical Specifications
| Molecular Formula | C7H8ClN3O4S2 |
| Molecular Weight | 296.96448 g/mol |
| XLogP | -0.1 |
| Topological Polar Surface Area (TPSA) | 135.0 Ų |
| Hydrogen Bond Donors | 3 |
| Hydrogen Bond Acceptors | 7 |
| Rotatable Bonds | 1 |
| Exact Mass | 296.96448 Da |
| Heavy Atoms | 17 |
| Complexity | 494.0 |
| Melting Point | 523 to 527 °F (NTP, 1992) |
| Density | 1.693 g/cu cm |
| Solubility | less than 0.1 mg/mL at 72.5 °F (NTP, 1992) |
| SMILES | C1NC2=CC(=C(C=C2S(=O)(=O)N1)S(=O)(=O)N)Cl |
| InChIKey | JZUFKLXOESDKRF-UHFFFAOYSA-N |
Product Description
Applications: Hydrochlorothiazide is used in pharmaceutical synthesis routes and API production, as well as heterocycle construction in medicinal chemistry and agrochemical discovery. It commonly serves as a versatile building block for organic synthesis. CoreyChem supplies Hydrochlorothiazide (CAS 58-93-5) with custom synthesis available from milligram to multi-kilogram scale, supported by COA, MSDS, and HPLC/NMR/MS documentation.
Hydrochlorothiazide (CAS 58-93-5) is a pharmaceutical intermediate with the molecular formula C7H8ClN3O4S2 and a molecular weight of 296.96 g/mol. Key physical properties include a density of 1.693 g/cu cm g/cm³, a solubility: less than 0.1 mg/mL at 72.5 °F (NTP, 1992). It is also known as hydrochlorothiazide and Esidrix.
Custom synthesis and full analytical documentation (COA/MSDS) are available from CoreyChem. Request a quotation with your required quantity and purity for current lead time and pricing.
Chemical Property Profile of Hydrochlorothiazide
Property Insights of Hydrochlorothiazide
The XLogP value of -0.1 indicates that Hydrochlorothiazide is hydrophilic (water-soluble), making it suitable for aqueous formulations and biological assay applications. The TPSA of 135.0 Ų falls within the moderate polarity range, balancing permeability and solubility for Hydrochlorothiazide. Following Lipinski's Rule of Five, Hydrochlorothiazide has 3 hydrogen bond donor(s) and 7 hydrogen bond acceptor(s), all within the drug-like range, suggesting favorable oral bioavailability potential.
Frequently Asked Questions
What is the CAS number of Hydrochlorothiazide?
The CAS number of Hydrochlorothiazide is 58-93-5.
What is the molecular formula of Hydrochlorothiazide?
The molecular formula of Hydrochlorothiazide is C7H8ClN3O4S2.
What is the molecular weight of Hydrochlorothiazide?
The molecular weight of Hydrochlorothiazide is 296.96448 g/mol.
What are the applications of Hydrochlorothiazide?
Hydrochlorothiazide is used in pharmaceutical synthesis routes and API production, as well as heterocycle construction in medicinal chemistry and agrochemical discovery. It commonly serves as a versatile building block for organic synthesis. CoreyChem supplies Hydrochlorothiazide (CAS 58-93-5)...
Where can I buy Hydrochlorothiazide?
You can request a quote for Hydrochlorothiazide directly from CoreyChem. Contact us or email [email protected] for pricing and availability.
Does CoreyChem offer custom synthesis for Hydrochlorothiazide?
Yes, CoreyChem provides custom synthesis services for Hydrochlorothiazide and related compounds. Contact us with your specific requirements including quantity, purity, and timeline.