Azelastine
TL;DR: Azelastine (CAS 58581-89-8) is a chemical compound with molecular formula C22H24ClN3O and molecular weight 381.1608 g/mol, supplied by CoreyChem (Career Henan Chemical Co., Ltd.) with ISO-certified quality and global shipping.
4-[(4-chlorophenyl)methyl]-2-(1-methylazepan-4-yl)phthalazin-1-one
Also Known As: azelastine, Azelastina, Azelastinum, Astelin, Optivar
Application Areas
Top 5 of 16 IPC patent classification(s) from the SureChEMBL global patent database.
Technical Specifications
| Molecular Formula | C22H24ClN3O |
| Molecular Weight | 381.1608 g/mol |
| XLogP | 4.4 |
| Topological Polar Surface Area (TPSA) | 35.9 Ų |
| Hydrogen Bond Donors | 0 |
| Hydrogen Bond Acceptors | 3 |
| Rotatable Bonds | 3 |
| Exact Mass | 381.1608 Da |
| Heavy Atoms | 27 |
| Complexity | 558.0 |
| Melting Point | 225 |
| Solubility | Sparingly soluble (hydrochloride salt) |
| SMILES | CN1CCCC(CC1)N2C(=O)C3=CC=CC=C3C(=N2)CC4=CC=C(C=C4)Cl |
| InChIKey | MBUVEWMHONZEQD-UHFFFAOYSA-N |
Product Description
Applications: Azelastine is used in pharmaceutical synthesis routes and API production, as well as heterocycle construction in medicinal chemistry and agrochemical discovery. It commonly serves as a versatile building block for organic synthesis. Available from CoreyChem as both catalog item and custom-synthesis project (mg to ton scale), with full analytical documentation (COA, MSDS, HPLC, NMR, MS).
A pharmaceutical intermediate supplied by CoreyChem, Azelastine (CAS 58581-89-8) has the molecular formula C22H24ClN3O and a molecular weight of 381.16 g/mol. Reported properties include a solubility: Sparingly soluble (hydrochloride salt). Synonyms include azelastine and Azelastina.
Custom synthesis and full analytical documentation (COA/MSDS) are available from CoreyChem. Request a quotation with your required quantity and purity for current lead time and pricing.
Chemical Property Profile of Azelastine
Property Insights of Azelastine
The XLogP value of 4.4 indicates that Azelastine is lipophilic (fat-soluble), which may influence its absorption, distribution, and formulation strategy. With a topological polar surface area (TPSA) of 35.9 Ų, Azelastine exhibits relatively low polarity, potentially indicating favorable cell membrane permeability. Following Lipinski's Rule of Five, Azelastine has 0 hydrogen bond donor(s) and 3 hydrogen bond acceptor(s), all within the drug-like range, suggesting favorable oral bioavailability potential.
Frequently Asked Questions
What is the CAS number of Azelastine?
The CAS number of Azelastine is 58581-89-8.
What is the molecular formula of Azelastine?
The molecular formula of Azelastine is C22H24ClN3O.
What is the molecular weight of Azelastine?
The molecular weight of Azelastine is 381.1608 g/mol.
What are the applications of Azelastine?
Azelastine is used in pharmaceutical synthesis routes and API production, as well as heterocycle construction in medicinal chemistry and agrochemical discovery. It commonly serves as a versatile building block for organic synthesis. Available from CoreyChem as both catalog item and...
Where can I buy Azelastine?
You can request a quote for Azelastine directly from CoreyChem. Contact us or email [email protected] for pricing and availability.
Does CoreyChem offer custom synthesis for Azelastine?
Yes, CoreyChem provides custom synthesis services for Azelastine and related compounds. Contact us with your specific requirements including quantity, purity, and timeline.