Acetazolamide
TL;DR: Acetazolamide (CAS 59-66-5) is a chemical compound with molecular formula C4H6N4O3S2 and molecular weight 221.98813 g/mol, supplied by CoreyChem (Career Henan Chemical Co., Ltd.) with ISO-certified quality and global shipping.
N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide
Also Known As: acetazolamide, Acetamox, Diamox, Glaupax, Edemox
Application Areas
Top 5 of 18 IPC patent classification(s) from the SureChEMBL global patent database.
Technical Specifications
| Molecular Formula | C4H6N4O3S2 |
| Molecular Weight | 221.98813 g/mol |
| XLogP | -0.3 |
| Topological Polar Surface Area (TPSA) | 152.0 Ų |
| Hydrogen Bond Donors | 2 |
| Hydrogen Bond Acceptors | 7 |
| Rotatable Bonds | 2 |
| Exact Mass | 221.98813 Da |
| Heavy Atoms | 13 |
| Complexity | 297.0 |
| Melting Point | 496 to 498 °F (effervescence) (NTP, 1992) |
| Solubility | less than 1 mg/mL at 72 °F (NTP, 1992) |
| SMILES | CC(=O)NC1=NN=C(S1)S(=O)(=O)N |
| InChIKey | BZKPWHYZMXOIDC-UHFFFAOYSA-N |
Product Description
Applications: Acetazolamide is used in pharmaceutical synthesis routes and API production, as well as heterocycle construction in medicinal chemistry and agrochemical discovery. It commonly serves as a versatile building block for organic synthesis. Available from CoreyChem as both catalog item and custom-synthesis project (mg to ton scale), with full analytical documentation (COA, MSDS, HPLC, NMR, MS).
Acetazolamide is a pharmaceutical intermediate identified by CAS number 59-66-5 and the molecular formula C4H6N4O3S2 and a molecular weight of 221.99 g/mol. Physically, the compound has a solubility: less than 1 mg/mL at 72 °F (NTP, 1992). Synonyms include acetazolamide and Acetamox.
Custom synthesis and full analytical documentation (COA/MSDS) are available from CoreyChem. Request a quotation with your required quantity and purity for current lead time and pricing.
Chemical Property Profile of Acetazolamide
Property Insights of Acetazolamide
The XLogP value of -0.3 indicates that Acetazolamide is hydrophilic (water-soluble), making it suitable for aqueous formulations and biological assay applications. The TPSA of 152.0 Ų indicates high polarity, suggesting Acetazolamide may have limited membrane permeability but good aqueous solubility. Following Lipinski's Rule of Five, Acetazolamide has 2 hydrogen bond donor(s) and 7 hydrogen bond acceptor(s), all within the drug-like range, suggesting favorable oral bioavailability potential.
Frequently Asked Questions
What is the CAS number of Acetazolamide?
The CAS number of Acetazolamide is 59-66-5.
What is the molecular formula of Acetazolamide?
The molecular formula of Acetazolamide is C4H6N4O3S2.
What is the molecular weight of Acetazolamide?
The molecular weight of Acetazolamide is 221.98813 g/mol.
What are the applications of Acetazolamide?
Acetazolamide is used in pharmaceutical synthesis routes and API production, as well as heterocycle construction in medicinal chemistry and agrochemical discovery. It commonly serves as a versatile building block for organic synthesis. Available from CoreyChem as both catalog item and...
Where can I buy Acetazolamide?
You can request a quote for Acetazolamide directly from CoreyChem. Contact us or email [email protected] for pricing and availability.
Does CoreyChem offer custom synthesis for Acetazolamide?
Yes, CoreyChem provides custom synthesis services for Acetazolamide and related compounds. Contact us with your specific requirements including quantity, purity, and timeline.