Promethazine
TL;DR: Promethazine (CAS 60-87-7) is a chemical compound with molecular formula C17H20N2S and molecular weight 284.1347 g/mol, supplied by CoreyChem (Career Henan Chemical Co., Ltd.) with ISO-certified quality and global shipping.
N,N-dimethyl-1-phenothiazin-10-ylpropan-2-amine
Also Known As: promethazine, Proazamine, Vallergine, Diphergan, Protazine
Application Areas
Top 5 of 18 IPC patent classification(s) from the SureChEMBL global patent database.
Technical Specifications
| Molecular Formula | C17H20N2S |
| Molecular Weight | 284.1347 g/mol |
| XLogP | 4.8 |
| Topological Polar Surface Area (TPSA) | 31.8 Ų |
| Hydrogen Bond Donors | 0 |
| Hydrogen Bond Acceptors | 3 |
| Rotatable Bonds | 3 |
| Exact Mass | 284.1347 Da |
| Heavy Atoms | 20 |
| Complexity | 298.0 |
| Melting Point | 140 °F (NTP, 1992) |
| Boiling Point | 374 to 379 °F at 3 mmHg (NTP, 1992) |
| Solubility | 15.6 |
| SMILES | CC(CN1C2=CC=CC=C2SC3=CC=CC=C31)N(C)C |
| InChIKey | PWWVAXIEGOYWEE-UHFFFAOYSA-N |
Product Description
Applications: Promethazine is used in pharmaceutical synthesis routes and API production, as well as heterocycle construction in medicinal chemistry and agrochemical discovery. It commonly serves as a versatile building block for organic synthesis. CoreyChem supplies Promethazine (CAS 60-87-7) with custom synthesis available from milligram to multi-kilogram scale, supported by COA, MSDS, and HPLC/NMR/MS documentation.
A pharmaceutical intermediate supplied by CoreyChem, Promethazine (CAS 60-87-7) has the molecular formula C17H20N2S and a molecular weight of 284.13 g/mol. Reported properties include a solubility: 15.6. It is also known as promethazine and Proazamine.
Custom synthesis and full analytical documentation (COA/MSDS) are available from CoreyChem. Request a quotation with your required quantity and purity for current lead time and pricing.
Chemical Property Profile of Promethazine
Property Insights of Promethazine
The XLogP value of 4.8 indicates that Promethazine is lipophilic (fat-soluble), which may influence its absorption, distribution, and formulation strategy. With a topological polar surface area (TPSA) of 31.8 Ų, Promethazine exhibits relatively low polarity, potentially indicating favorable cell membrane permeability. Following Lipinski's Rule of Five, Promethazine has 0 hydrogen bond donor(s) and 3 hydrogen bond acceptor(s), all within the drug-like range, suggesting favorable oral bioavailability potential.
Frequently Asked Questions
What is the CAS number of Promethazine?
The CAS number of Promethazine is 60-87-7.
What is the molecular formula of Promethazine?
The molecular formula of Promethazine is C17H20N2S.
What is the molecular weight of Promethazine?
The molecular weight of Promethazine is 284.1347 g/mol.
What are the applications of Promethazine?
Promethazine is used in pharmaceutical synthesis routes and API production, as well as heterocycle construction in medicinal chemistry and agrochemical discovery. It commonly serves as a versatile building block for organic synthesis. CoreyChem supplies Promethazine (CAS 60-87-7) with custom...
Where can I buy Promethazine?
You can request a quote for Promethazine directly from CoreyChem. Contact us or email [email protected] for pricing and availability.
Does CoreyChem offer custom synthesis for Promethazine?
Yes, CoreyChem provides custom synthesis services for Promethazine and related compounds. Contact us with your specific requirements including quantity, purity, and timeline.