Tolbutamide
TL;DR: Tolbutamide (CAS 64-77-7) is a chemical compound with molecular formula C12H18N2O3S and molecular weight 270.10382 g/mol, supplied by CoreyChem (Career Henan Chemical Co., Ltd.) with ISO-certified quality and global shipping.
1-butyl-3-(4-methylphenyl)sulfonylurea
Also Known As: tolbutamide, Orinase, Diabetamid, Butamide, Arkozal
Application Areas
Top 5 of 17 IPC patent classification(s) from the SureChEMBL global patent database.
Technical Specifications
| Molecular Formula | C12H18N2O3S |
| Molecular Weight | 270.10382 g/mol |
| XLogP | 2.3 |
| Topological Polar Surface Area (TPSA) | 83.7 Ų |
| Hydrogen Bond Donors | 2 |
| Hydrogen Bond Acceptors | 3 |
| Rotatable Bonds | 5 |
| Exact Mass | 270.10382 Da |
| Heavy Atoms | 18 |
| Complexity | 354.0 |
| Melting Point | 262 to 264 °F (NTP, 1992) |
| Density | 1.245 at 77 °F (NTP, 1992) - Denser than water; will sink |
| Solubility | less than 1 mg/mL at 61 °F (NTP, 1992) |
| SMILES | CCCCNC(=O)NS(=O)(=O)C1=CC=C(C=C1)C |
| InChIKey | JLRGJRBPOGGCBT-UHFFFAOYSA-N |
Product Description
Applications: Tolbutamide is used in pharmaceutical synthesis routes and API production, as well as heterocycle construction in medicinal chemistry and agrochemical discovery. It commonly serves as a versatile building block for organic synthesis. Available from CoreyChem as both catalog item and custom-synthesis project (mg to ton scale), with full analytical documentation (COA, MSDS, HPLC, NMR, MS).
Tolbutamide (CAS 64-77-7) is a pharmaceutical intermediate with the molecular formula C12H18N2O3S and a molecular weight of 270.1 g/mol. Key physical properties include a density of 1.245 at 77 °F (NTP, 1992) - Denser than water; will sink g/cm³, a solubility: less than 1 mg/mL at 61 °F (NTP, 1992). Synonyms include tolbutamide and Orinase.
Custom synthesis and full analytical documentation (COA/MSDS) are available from CoreyChem. Request a quotation with your required quantity and purity for current lead time and pricing.
Chemical Property Profile of Tolbutamide
Property Insights of Tolbutamide
The XLogP value of 2.3 suggests moderate lipophilicity, balancing water solubility and membrane permeability for Tolbutamide. The TPSA of 83.7 Ų falls within the moderate polarity range, balancing permeability and solubility for Tolbutamide. Following Lipinski's Rule of Five, Tolbutamide has 2 hydrogen bond donor(s) and 3 hydrogen bond acceptor(s), all within the drug-like range, suggesting favorable oral bioavailability potential.
Frequently Asked Questions
What is the CAS number of Tolbutamide?
The CAS number of Tolbutamide is 64-77-7.
What is the molecular formula of Tolbutamide?
The molecular formula of Tolbutamide is C12H18N2O3S.
What is the molecular weight of Tolbutamide?
The molecular weight of Tolbutamide is 270.10382 g/mol.
What are the applications of Tolbutamide?
Tolbutamide is used in pharmaceutical synthesis routes and API production, as well as heterocycle construction in medicinal chemistry and agrochemical discovery. It commonly serves as a versatile building block for organic synthesis. Available from CoreyChem as both catalog item and...
Where can I buy Tolbutamide?
You can request a quote for Tolbutamide directly from CoreyChem. Contact us or email [email protected] for pricing and availability.
Does CoreyChem offer custom synthesis for Tolbutamide?
Yes, CoreyChem provides custom synthesis services for Tolbutamide and related compounds. Contact us with your specific requirements including quantity, purity, and timeline.