Hydroxyzine
TL;DR: Hydroxyzine (CAS 68-88-2) is a chemical compound with molecular formula C21H27ClN2O2 and molecular weight 374.17612 g/mol, supplied by CoreyChem (Career Henan Chemical Co., Ltd.) with ISO-certified quality and global shipping.
2-[2-[4-[(4-chlorophenyl)-phenylmethyl]piperazin-1-yl]ethoxy]ethanol
Also Known As: hydroxyzine, Hydroxizine, Hydroxyzin, Hydroxycine, Hydroxine
Application Areas
Top 5 of 16 IPC patent classification(s) from the SureChEMBL global patent database.
Technical Specifications
| Molecular Formula | C21H27ClN2O2 |
| Molecular Weight | 374.17612 g/mol |
| XLogP | 3.7 |
| Topological Polar Surface Area (TPSA) | 35.9 Ų |
| Hydrogen Bond Donors | 1 |
| Hydrogen Bond Acceptors | 4 |
| Rotatable Bonds | 8 |
| Exact Mass | 374.17612 Da |
| Heavy Atoms | 26 |
| Complexity | 376.0 |
| Melting Point | 200C |
| Boiling Point | 220 °C at 0.5 mm Hg |
| Solubility | Crystals; MP 193 °C; Bitter taste. Solubility in mg/mL: water <700; chloroform 60; acetone 2; ether <0.1. Solutions are unstable to intense UV light. /Hydroxyzine dihydrochloride/ |
| SMILES | C1CN(CCN1CCOCCO)C(C2=CC=CC=C2)C3=CC=C(C=C3)Cl |
| InChIKey | ZQDWXGKKHFNSQK-UHFFFAOYSA-N |
Product Description
Applications: Hydroxyzine is used in pharmaceutical synthesis routes and API production, as well as heterocycle construction in medicinal chemistry and agrochemical discovery. It commonly serves as a versatile building block for organic synthesis. Available from CoreyChem as both catalog item and custom-synthesis project (mg to ton scale), with full analytical documentation (COA, MSDS, HPLC, NMR, MS).
A pharmaceutical intermediate supplied by CoreyChem, Hydroxyzine (CAS 68-88-2) has the molecular formula C21H27ClN2O2 and a molecular weight of 374.18 g/mol. Reported properties include a solubility: Crystals; MP 193 °C; Bitter taste. Solubility in mg/mL: water <700; chloroform 60; acetone 2; ether <0.1. Solutions are unstable to intense UV light. /Hydroxyzine dihydrochloride/. Synonyms include hydroxyzine and Hydroxizine.
Custom synthesis and full analytical documentation (COA/MSDS) are available from CoreyChem. Request a quotation with your required quantity and purity for current lead time and pricing.
Chemical Property Profile of Hydroxyzine
Property Insights of Hydroxyzine
The XLogP value of 3.7 indicates that Hydroxyzine is lipophilic (fat-soluble), which may influence its absorption, distribution, and formulation strategy. With a topological polar surface area (TPSA) of 35.9 Ų, Hydroxyzine exhibits relatively low polarity, potentially indicating favorable cell membrane permeability. Following Lipinski's Rule of Five, Hydroxyzine has 1 hydrogen bond donor(s) and 4 hydrogen bond acceptor(s), all within the drug-like range, suggesting favorable oral bioavailability potential.
Frequently Asked Questions
What is the CAS number of Hydroxyzine?
The CAS number of Hydroxyzine is 68-88-2.
What is the molecular formula of Hydroxyzine?
The molecular formula of Hydroxyzine is C21H27ClN2O2.
What is the molecular weight of Hydroxyzine?
The molecular weight of Hydroxyzine is 374.17612 g/mol.
What are the applications of Hydroxyzine?
Hydroxyzine is used in pharmaceutical synthesis routes and API production, as well as heterocycle construction in medicinal chemistry and agrochemical discovery. It commonly serves as a versatile building block for organic synthesis. Available from CoreyChem as both catalog item and...
Where can I buy Hydroxyzine?
You can request a quote for Hydroxyzine directly from CoreyChem. Contact us or email [email protected] for pricing and availability.
Does CoreyChem offer custom synthesis for Hydroxyzine?
Yes, CoreyChem provides custom synthesis services for Hydroxyzine and related compounds. Contact us with your specific requirements including quantity, purity, and timeline.