Trichlorofluoromethane
TL;DR: Trichlorofluoromethane (CAS 75-69-4) is a chemical compound with molecular formula CCl3F and molecular weight 135.90497 g/mol, supplied by CoreyChem (Career Henan Chemical Co., Ltd.) with ISO-certified quality and global shipping.
trichloro(fluoro)methane
Also Known As: Trichlorofluoromethane, Fluorotrichloromethane, Fluorochloroform, trichloro(fluoro)methane, Algofrene type 1
Application Areas
Top 5 of 22 IPC patent classification(s) from the SureChEMBL global patent database.
Technical Specifications
| Molecular Formula | CCl3F |
| Molecular Weight | 135.90497 g/mol |
| XLogP | 2.5 |
| Topological Polar Surface Area (TPSA) | 0.0 Ų |
| Hydrogen Bond Donors | 0 |
| Hydrogen Bond Acceptors | 1 |
| Rotatable Bonds | 0 |
| Exact Mass | 135.90497 Da |
| Heavy Atoms | 5 |
| Complexity | 28.0 |
| Melting Point | -168 °F (NTP, 1992) |
| Boiling Point | 74.7 °F at 760 mmHg (NTP, 1992) |
| Density | 1.49 at 63 °F (NTP, 1992) - Denser than water; will sink |
| Vapor Pressure | 792 mmHg at 77 °F (NTP, 1992) |
| Refractive Index | Index of refraction: 1.3865 @ 18.5 °C/D |
| Solubility | 10 to 50 mg/mL at 64 °F (NTP, 1992) |
| SMILES | C(F)(Cl)(Cl)Cl |
| InChIKey | CYRMSUTZVYGINF-UHFFFAOYSA-N |
Product Description
Applications: Trichlorofluoromethane is used in pharmaceutical synthesis routes and API production, as well as heterocycle construction in medicinal chemistry and agrochemical discovery. It commonly serves as a versatile building block for organic synthesis. Available from CoreyChem as both catalog item and custom-synthesis project (mg to ton scale), with full analytical documentation (COA, MSDS, HPLC, NMR, MS).
Trichlorofluoromethane (CAS 75-69-4) is a pharmaceutical intermediate with the molecular formula CCl3F and a molecular weight of 135.9 g/mol. Key physical properties include a density of 1.49 at 63 °F (NTP, 1992) - Denser than water; will sink g/cm³, a solubility: 10 to 50 mg/mL at 64 °F (NTP, 1992). Synonyms include Trichlorofluoromethane and Fluorotrichloromethane.
Custom synthesis and full analytical documentation (COA/MSDS) are available from CoreyChem. Request a quotation with your required quantity and purity for current lead time and pricing.
Chemical Property Profile of Trichlorofluoromethane
Property Insights of Trichlorofluoromethane
The XLogP value of 2.5 suggests moderate lipophilicity, balancing water solubility and membrane permeability for Trichlorofluoromethane. With a topological polar surface area (TPSA) of 0.0 Ų, Trichlorofluoromethane exhibits relatively low polarity, potentially indicating favorable cell membrane permeability. Following Lipinski's Rule of Five, Trichlorofluoromethane has 0 hydrogen bond donor(s) and 1 hydrogen bond acceptor(s), all within the drug-like range, suggesting favorable oral bioavailability potential.
Frequently Asked Questions
What is the CAS number of Trichlorofluoromethane?
The CAS number of Trichlorofluoromethane is 75-69-4.
What is the molecular formula of Trichlorofluoromethane?
The molecular formula of Trichlorofluoromethane is CCl3F.
What is the molecular weight of Trichlorofluoromethane?
The molecular weight of Trichlorofluoromethane is 135.90497 g/mol.
What are the applications of Trichlorofluoromethane?
Trichlorofluoromethane is used in pharmaceutical synthesis routes and API production, as well as heterocycle construction in medicinal chemistry and agrochemical discovery. It commonly serves as a versatile building block for organic synthesis. Available from CoreyChem as both catalog item and...
Where can I buy Trichlorofluoromethane?
You can request a quote for Trichlorofluoromethane directly from CoreyChem. Contact us or email [email protected] for pricing and availability.
Does CoreyChem offer custom synthesis for Trichlorofluoromethane?
Yes, CoreyChem provides custom synthesis services for Trichlorofluoromethane and related compounds. Contact us with your specific requirements including quantity, purity, and timeline.