Chlorotrimethylsilane
TL;DR: Chlorotrimethylsilane (CAS 75-77-4) is a chemical compound with molecular formula C3H9ClSi and molecular weight 108.016205 g/mol, supplied by CoreyChem (Career Henan Chemical Co., Ltd.) with ISO-certified quality and global shipping.
chloro(trimethyl)silane
Also Known As: Chlorotrimethylsilane, TRIMETHYLCHLOROSILANE, Trimethylsilyl chloride, chloro(trimethyl)silane, Trimethyl chlorosilane
Application Areas
Top 5 of 22 IPC patent classification(s) from the SureChEMBL global patent database.
Technical Specifications
| Molecular Formula | C3H9ClSi |
| Molecular Weight | 108.016205 g/mol |
| XLogP | 2.06 |
| Topological Polar Surface Area (TPSA) | 0.0 Ų |
| Hydrogen Bond Donors | 0 |
| Hydrogen Bond Acceptors | 0 |
| Rotatable Bonds | 0 |
| Exact Mass | 108.016205 Da |
| Heavy Atoms | 5 |
| Complexity | 28.0 |
| Melting Point | -72 °F (EPA, 1998) |
| Boiling Point | 135 °F at 760 mmHg (EPA, 1998) |
| Density | 0.854 at 77 °F (EPA, 1998) - Less dense than water; will float |
| Flash Point | 0 °F (EPA, 1998) |
| Vapor Pressure | 608 mmHg at 68 °F ; 40 mmHg at 11.5 °F; 100 mmHg at 42.8 °F (NTP, 1992) |
| Refractive Index | Index of refraction = 1.3870 at 25 °C/D |
| Solubility | Decomposes (NTP, 1992) |
| SMILES | C[Si](C)(C)Cl |
| InChIKey | IJOOHPMOJXWVHK-UHFFFAOYSA-N |
Product Description
Applications: Chlorotrimethylsilane is used in heterocycle construction in medicinal chemistry and agrochemical discovery, as well as pharmaceutical synthesis routes and API production. It commonly serves as a versatile building block for organic synthesis. CoreyChem supplies Chlorotrimethylsilane (CAS 75-77-4) with custom synthesis available from milligram to multi-kilogram scale, supported by COA, MSDS, and HPLC/NMR/MS documentation.
Chlorotrimethylsilane (CAS 75-77-4) is a heterocyclic building block with the molecular formula C3H9ClSi and a molecular weight of 108.02 g/mol. Key physical properties include a density of 0.854 at 77 °F (EPA, 1998) - Less dense than water; will float g/cm³, a solubility: Decomposes (NTP, 1992). It is also known as Chlorotrimethylsilane and TRIMETHYLCHLOROSILANE.
Custom synthesis and full analytical documentation (COA/MSDS) are available from CoreyChem. Request a quotation with your required quantity and purity for current lead time and pricing.
Chemical Property Profile of Chlorotrimethylsilane
Property Insights of Chlorotrimethylsilane
The XLogP value of 2.06 suggests moderate lipophilicity, balancing water solubility and membrane permeability for Chlorotrimethylsilane. With a topological polar surface area (TPSA) of 0.0 Ų, Chlorotrimethylsilane exhibits relatively low polarity, potentially indicating favorable cell membrane permeability. Following Lipinski's Rule of Five, Chlorotrimethylsilane has 0 hydrogen bond donor(s) and 0 hydrogen bond acceptor(s), all within the drug-like range, suggesting favorable oral bioavailability potential.
Frequently Asked Questions
What is the CAS number of Chlorotrimethylsilane?
The CAS number of Chlorotrimethylsilane is 75-77-4.
What is the molecular formula of Chlorotrimethylsilane?
The molecular formula of Chlorotrimethylsilane is C3H9ClSi.
What is the molecular weight of Chlorotrimethylsilane?
The molecular weight of Chlorotrimethylsilane is 108.016205 g/mol.
What are the applications of Chlorotrimethylsilane?
Chlorotrimethylsilane is used in heterocycle construction in medicinal chemistry and agrochemical discovery, as well as pharmaceutical synthesis routes and API production. It commonly serves as a versatile building block for organic synthesis. CoreyChem supplies Chlorotrimethylsilane (CAS...
Where can I buy Chlorotrimethylsilane?
You can request a quote for Chlorotrimethylsilane directly from CoreyChem. Contact us or email [email protected] for pricing and availability.
Does CoreyChem offer custom synthesis for Chlorotrimethylsilane?
Yes, CoreyChem provides custom synthesis services for Chlorotrimethylsilane and related compounds. Contact us with your specific requirements including quantity, purity, and timeline.
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