Leflunomide
TL;DR: Leflunomide (CAS 75706-12-6) is a chemical compound with molecular formula C12H9F3N2O2 and molecular weight 270.0616 g/mol, supplied by CoreyChem (Career Henan Chemical Co., Ltd.) with ISO-certified quality and global shipping.
5-methyl-N-[4-(trifluoromethyl)phenyl]-1,2-oxazole-4-carboxamide
Also Known As: leflunomide, Arava, Leflunomida, Leflunomidum, lefunamide
Application Areas
Top 5 of 13 IPC patent classification(s) from the SureChEMBL global patent database.
Technical Specifications
| Molecular Formula | C12H9F3N2O2 |
| Molecular Weight | 270.0616 g/mol |
| XLogP | 2.5 |
| Topological Polar Surface Area (TPSA) | 55.1 Ų |
| Hydrogen Bond Donors | 1 |
| Hydrogen Bond Acceptors | 6 |
| Rotatable Bonds | 2 |
| Exact Mass | 270.0616 Da |
| Heavy Atoms | 19 |
| Complexity | 327.0 |
| Melting Point | 165-166 °C |
| Vapor Pressure | 1.25X10-6 mm Hg at 25 °C /Estimated/ |
| Solubility | 21 |
| SMILES | CC1=C(C=NO1)C(=O)NC2=CC=C(C=C2)C(F)(F)F |
| InChIKey | VHOGYURTWQBHIL-UHFFFAOYSA-N |
Product Description
Applications: Leflunomide is used in pharmaceutical synthesis routes and API production, as well as heterocycle construction in medicinal chemistry and agrochemical discovery. It commonly serves as a versatile building block for organic synthesis. CoreyChem supplies Leflunomide (CAS 75706-12-6) with custom synthesis available from milligram to multi-kilogram scale, supported by COA, MSDS, and HPLC/NMR/MS documentation.
Leflunomide is a pharmaceutical intermediate identified by CAS number 75706-12-6 and the molecular formula C12H9F3N2O2 and a molecular weight of 270.06 g/mol. Physically, the compound has a solubility: 21. It is also known as leflunomide and Arava.
Custom synthesis and full analytical documentation (COA/MSDS) are available from CoreyChem. Request a quotation with your required quantity and purity for current lead time and pricing.
Chemical Property Profile of Leflunomide
Property Insights of Leflunomide
The XLogP value of 2.5 suggests moderate lipophilicity, balancing water solubility and membrane permeability for Leflunomide. With a topological polar surface area (TPSA) of 55.1 Ų, Leflunomide exhibits relatively low polarity, potentially indicating favorable cell membrane permeability. Following Lipinski's Rule of Five, Leflunomide has 1 hydrogen bond donor(s) and 6 hydrogen bond acceptor(s), all within the drug-like range, suggesting favorable oral bioavailability potential.
Frequently Asked Questions
What is the CAS number of Leflunomide?
The CAS number of Leflunomide is 75706-12-6.
What is the molecular formula of Leflunomide?
The molecular formula of Leflunomide is C12H9F3N2O2.
What is the molecular weight of Leflunomide?
The molecular weight of Leflunomide is 270.0616 g/mol.
What are the applications of Leflunomide?
Leflunomide is used in pharmaceutical synthesis routes and API production, as well as heterocycle construction in medicinal chemistry and agrochemical discovery. It commonly serves as a versatile building block for organic synthesis. CoreyChem supplies Leflunomide (CAS 75706-12-6) with custom...
Where can I buy Leflunomide?
You can request a quote for Leflunomide directly from CoreyChem. Contact us or email [email protected] for pricing and availability.
Does CoreyChem offer custom synthesis for Leflunomide?
Yes, CoreyChem provides custom synthesis services for Leflunomide and related compounds. Contact us with your specific requirements including quantity, purity, and timeline.