Loratadine
TL;DR: Loratadine (CAS 79794-75-5) is a chemical compound with molecular formula C22H23ClN2O2 and molecular weight 382.1448 g/mol, supplied by CoreyChem (Career Henan Chemical Co., Ltd.) with ISO-certified quality and global shipping.
ethyl 4-(13-chloro-4-azatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-ylidene)piperidine-1-carboxylate
Also Known As: loratadine, Claritin, Clarityn, Alavert, Loratidine
Application Areas
Top 5 of 22 IPC patent classification(s) from the SureChEMBL global patent database.
Technical Specifications
| Molecular Formula | C22H23ClN2O2 |
| Molecular Weight | 382.1448 g/mol |
| XLogP | 5.2 |
| Topological Polar Surface Area (TPSA) | 42.4 Ų |
| Hydrogen Bond Donors | 0 |
| Hydrogen Bond Acceptors | 3 |
| Rotatable Bonds | 2 |
| Exact Mass | 382.1448 Da |
| Heavy Atoms | 27 |
| Complexity | 569.0 |
| Melting Point | 134-136 °C |
| Solubility | <1 mg/ml at 25°C |
| SMILES | CCOC(=O)N1CCC(=C2C3=C(CCC4=C2N=CC=C4)C=C(C=C3)Cl)CC1 |
| InChIKey | JCCNYMKQOSZNPW-UHFFFAOYSA-N |
Product Description
Applications: Loratadine is used in pharmaceutical synthesis routes and API production, as well as heterocycle construction in medicinal chemistry and agrochemical discovery. It commonly serves as a versatile building block for organic synthesis. Available from CoreyChem as both catalog item and custom-synthesis project (mg to ton scale), with full analytical documentation (COA, MSDS, HPLC, NMR, MS).
Loratadine (CAS 79794-75-5) is a pharmaceutical intermediate with the molecular formula C22H23ClN2O2 and a molecular weight of 382.14 g/mol. Key physical properties include a solubility: <1 mg/ml at 25°C. Synonyms include loratadine and Claritin.
Custom synthesis and full analytical documentation (COA/MSDS) are available from CoreyChem. Request a quotation with your required quantity and purity for current lead time and pricing.
Chemical Property Profile of Loratadine
Property Insights of Loratadine
The XLogP value of 5.2 indicates that Loratadine is lipophilic (fat-soluble), which may influence its absorption, distribution, and formulation strategy. With a topological polar surface area (TPSA) of 42.4 Ų, Loratadine exhibits relatively low polarity, potentially indicating favorable cell membrane permeability. Following Lipinski's Rule of Five, Loratadine has 0 hydrogen bond donor(s) and 3 hydrogen bond acceptor(s), which may warrant consideration for formulation optimization.
Frequently Asked Questions
What is the CAS number of Loratadine?
The CAS number of Loratadine is 79794-75-5.
What is the molecular formula of Loratadine?
The molecular formula of Loratadine is C22H23ClN2O2.
What is the molecular weight of Loratadine?
The molecular weight of Loratadine is 382.1448 g/mol.
What are the applications of Loratadine?
Loratadine is used in pharmaceutical synthesis routes and API production, as well as heterocycle construction in medicinal chemistry and agrochemical discovery. It commonly serves as a versatile building block for organic synthesis. Available from CoreyChem as both catalog item and...
Where can I buy Loratadine?
You can request a quote for Loratadine directly from CoreyChem. Contact us or email [email protected] for pricing and availability.
Does CoreyChem offer custom synthesis for Loratadine?
Yes, CoreyChem provides custom synthesis services for Loratadine and related compounds. Contact us with your specific requirements including quantity, purity, and timeline.