Buclizine
TL;DR: Buclizine (CAS 82-95-1) is a chemical compound with molecular formula C28H33ClN2 and molecular weight 432.23322 g/mol, supplied by CoreyChem (Career Henan Chemical Co., Ltd.) with ISO-certified quality and global shipping.
1-[(4-tert-butylphenyl)methyl]-4-[(4-chlorophenyl)-phenylmethyl]piperazine
Also Known As: Buclizine, Histabutizine, Histabuticine, Histabutyzine, Buclifen
Application Areas
Top 5 of 13 IPC patent classification(s) from the SureChEMBL global patent database.
Technical Specifications
| Molecular Formula | C28H33ClN2 |
| Molecular Weight | 432.23322 g/mol |
| XLogP | 7.1 |
| Topological Polar Surface Area (TPSA) | 6.5 Ų |
| Hydrogen Bond Donors | 0 |
| Hydrogen Bond Acceptors | 2 |
| Rotatable Bonds | 6 |
| Exact Mass | 432.23322 Da |
| Heavy Atoms | 31 |
| Complexity | 514.0 |
| Boiling Point | 218 |
| Solubility | 2.46e-04 g/L |
| SMILES | CC(C)(C)C1=CC=C(C=C1)CN2CCN(CC2)C(C3=CC=CC=C3)C4=CC=C(C=C4)Cl |
| InChIKey | MOYGZHXDRJNJEP-UHFFFAOYSA-N |
Product Description
Applications: Buclizine is used in pharmaceutical synthesis routes and API production, as well as heterocycle construction in medicinal chemistry and agrochemical discovery. It commonly serves as a versatile building block for organic synthesis. Available from CoreyChem as both catalog item and custom-synthesis project (mg to ton scale), with full analytical documentation (COA, MSDS, HPLC, NMR, MS).
Buclizine (CAS 82-95-1) is a pharmaceutical intermediate with the molecular formula C28H33ClN2 and a molecular weight of 432.23 g/mol. Key physical properties include a solubility: 2.46e-04 g/L. Synonyms include Buclizine and Histabutizine.
Custom synthesis and full analytical documentation (COA/MSDS) are available from CoreyChem. Request a quotation with your required quantity and purity for current lead time and pricing.
Chemical Property Profile of Buclizine
Property Insights of Buclizine
The XLogP value of 7.1 indicates that Buclizine is lipophilic (fat-soluble), which may influence its absorption, distribution, and formulation strategy. With a topological polar surface area (TPSA) of 6.5 Ų, Buclizine exhibits relatively low polarity, potentially indicating favorable cell membrane permeability. Following Lipinski's Rule of Five, Buclizine has 0 hydrogen bond donor(s) and 2 hydrogen bond acceptor(s), which may warrant consideration for formulation optimization.
Frequently Asked Questions
What is the CAS number of Buclizine?
The CAS number of Buclizine is 82-95-1.
What is the molecular formula of Buclizine?
The molecular formula of Buclizine is C28H33ClN2.
What is the molecular weight of Buclizine?
The molecular weight of Buclizine is 432.23322 g/mol.
What are the applications of Buclizine?
Buclizine is used in pharmaceutical synthesis routes and API production, as well as heterocycle construction in medicinal chemistry and agrochemical discovery. It commonly serves as a versatile building block for organic synthesis. Available from CoreyChem as both catalog item and...
Where can I buy Buclizine?
You can request a quote for Buclizine directly from CoreyChem. Contact us or email [email protected] for pricing and availability.
Does CoreyChem offer custom synthesis for Buclizine?
Yes, CoreyChem provides custom synthesis services for Buclizine and related compounds. Contact us with your specific requirements including quantity, purity, and timeline.