Tetrahydrofuran
TL;DR: Tetrahydrofuran (CAS 109-99-9) is a chemical compound with molecular formula C4H8O and molecular weight 72.05752 g/mol, supplied by CoreyChem (Career Henan Chemical Co., Ltd.) with ISO-certified quality and global shipping.
oxolane
Also Known As: TETRAHYDROFURAN, Oxolane, Furanidine, Hydrofuran, Butylene oxide
Application Areas
Top 5 of 22 IPC patent classification(s) from the SureChEMBL global patent database.
Technical Specifications
| Molecular Formula | C4H8O |
| Molecular Weight | 72.05752 g/mol |
| XLogP | 0.5 |
| Topological Polar Surface Area (TPSA) | 9.2 Ų |
| Hydrogen Bond Donors | 0 |
| Hydrogen Bond Acceptors | 1 |
| Rotatable Bonds | 0 |
| Exact Mass | 72.05752 Da |
| Heavy Atoms | 5 |
| Complexity | 22.0 |
| Purity | ≥99.0% |
| Melting Point | -163.3 °F (NTP, 1992) |
| Boiling Point | 151 °F at 760 mmHg (NTP, 1992) |
| Density | 0.888 at 68 °F (USCG, 1999) - Less dense than water; will float |
| Flash Point | 6 °F (NTP, 1992) |
| Vapor Pressure | 114 mmHg at 59 °F ; 145 mmHg at 68 °F (NTP, 1992) |
| Refractive Index | Index of refraction: 1.4050 at 20 °C/D |
| Solubility | greater than or equal to 100 mg/mL at 68 °F (NTP, 1992) |
| SMILES | C1CCOC1 |
| InChIKey | WYURNTSHIVDZCO-UHFFFAOYSA-N |
Product Description
Applications: Tetrahydrofuran is used in heterocycle construction in medicinal chemistry and agrochemical discovery, as well as pharmaceutical synthesis routes and API production. It commonly serves as a versatile building block for organic synthesis. Typical specifications: commercial lots are supplied at ≥99.0%. CoreyChem supplies Tetrahydrofuran (CAS 109-99-9) with custom synthesis available from milligram to multi-kilogram scale, supported by COA, MSDS, and HPLC/NMR/MS documentation.
A heterocyclic building block supplied by CoreyChem, Tetrahydrofuran (CAS 109-99-9) has the molecular formula C4H8O and a molecular weight of 72.06 g/mol. Reported properties include a density of 0.888 at 68 °F (USCG, 1999) - Less dense than water; will float g/cm³, a solubility: greater than or equal to 100 mg/mL at 68 °F (NTP, 1992). It is also known as TETRAHYDROFURAN and Oxolane.
CoreyChem provides it with COA documentation, and custom synthesis from milligram to multi-kilogram scales is available on request. Request a quotation with your required quantity and purity for current lead time and pricing.
Safety Information
H225, H302, H319, H335, H336, H351, H019
Chemical Property Profile of Tetrahydrofuran
Property Insights of Tetrahydrofuran
The XLogP value of 0.5 suggests moderate lipophilicity, balancing water solubility and membrane permeability for Tetrahydrofuran. With a topological polar surface area (TPSA) of 9.2 Ų, Tetrahydrofuran exhibits relatively low polarity, potentially indicating favorable cell membrane permeability. Following Lipinski's Rule of Five, Tetrahydrofuran has 0 hydrogen bond donor(s) and 1 hydrogen bond acceptor(s), all within the drug-like range, suggesting favorable oral bioavailability potential.
Frequently Asked Questions
What is the CAS number of Tetrahydrofuran?
The CAS number of Tetrahydrofuran is 109-99-9.
What is the molecular formula of Tetrahydrofuran?
The molecular formula of Tetrahydrofuran is C4H8O.
What is the molecular weight of Tetrahydrofuran?
The molecular weight of Tetrahydrofuran is 72.05752 g/mol.
What are the applications of Tetrahydrofuran?
Tetrahydrofuran is used in heterocycle construction in medicinal chemistry and agrochemical discovery, as well as pharmaceutical synthesis routes and API production. It commonly serves as a versatile building block for organic synthesis. Typical specifications: commercial lots are supplied at...
Where can I buy Tetrahydrofuran?
You can request a quote for Tetrahydrofuran directly from CoreyChem. Contact us or email [email protected] for pricing and availability.
Does CoreyChem offer custom synthesis for Tetrahydrofuran?
Yes, CoreyChem provides custom synthesis services for Tetrahydrofuran and related compounds. Contact us with your specific requirements including quantity, purity, and timeline.
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