Donepezil
TL;DR: Donepezil (CAS 120014-06-4) is a chemical compound with molecular formula C24H29NO3 and molecular weight 379.21475 g/mol, supplied by CoreyChem (Career Henan Chemical Co., Ltd.) with ISO-certified quality and global shipping.
2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one
Also Known As: donepezil, Aricept, donepezilo, Donaz, donepezilum
Application Areas
Top 5 of 16 IPC patent classification(s) from the SureChEMBL global patent database.
Technical Specifications
| Molecular Formula | C24H29NO3 |
| Molecular Weight | 379.21475 g/mol |
| XLogP | 4.3 |
| Topological Polar Surface Area (TPSA) | 38.8 Ų |
| Hydrogen Bond Donors | 0 |
| Hydrogen Bond Acceptors | 4 |
| Rotatable Bonds | 6 |
| Exact Mass | 379.21475 Da |
| Heavy Atoms | 28 |
| Complexity | 510.0 |
| Melting Point | 223-227 |
| Boiling Point | 527.9 |
| Solubility | 31mg/mL |
| SMILES | COC1=C(C=C2C(=C1)CC(C2=O)CC3CCN(CC3)CC4=CC=CC=C4)OC |
| InChIKey | ADEBPBSSDYVVLD-UHFFFAOYSA-N |
Product Description
Applications: Donepezil is used in pharmaceutical synthesis routes and API production, as well as heterocycle construction in medicinal chemistry and agrochemical discovery. It commonly serves as a versatile building block for organic synthesis. CoreyChem supplies Donepezil (CAS 120014-06-4) with custom synthesis available from milligram to multi-kilogram scale, supported by COA, MSDS, and HPLC/NMR/MS documentation.
Donepezil (CAS 120014-06-4) is a pharmaceutical intermediate with the molecular formula C24H29NO3 and a molecular weight of 379.21 g/mol. Key physical properties include a solubility: 31mg/mL. It is also known as donepezil and Aricept.
Custom synthesis and full analytical documentation (COA/MSDS) are available from CoreyChem. Request a quotation with your required quantity and purity for current lead time and pricing.
Chemical Property Profile of Donepezil
Property Insights of Donepezil
The XLogP value of 4.3 indicates that Donepezil is lipophilic (fat-soluble), which may influence its absorption, distribution, and formulation strategy. With a topological polar surface area (TPSA) of 38.8 Ų, Donepezil exhibits relatively low polarity, potentially indicating favorable cell membrane permeability. Following Lipinski's Rule of Five, Donepezil has 0 hydrogen bond donor(s) and 4 hydrogen bond acceptor(s), all within the drug-like range, suggesting favorable oral bioavailability potential.
Frequently Asked Questions
What is the CAS number of Donepezil?
The CAS number of Donepezil is 120014-06-4.
What is the molecular formula of Donepezil?
The molecular formula of Donepezil is C24H29NO3.
What is the molecular weight of Donepezil?
The molecular weight of Donepezil is 379.21475 g/mol.
What are the applications of Donepezil?
Donepezil is used in pharmaceutical synthesis routes and API production, as well as heterocycle construction in medicinal chemistry and agrochemical discovery. It commonly serves as a versatile building block for organic synthesis. CoreyChem supplies Donepezil (CAS 120014-06-4) with custom...
Where can I buy Donepezil?
You can request a quote for Donepezil directly from CoreyChem. Contact us or email [email protected] for pricing and availability.
Does CoreyChem offer custom synthesis for Donepezil?
Yes, CoreyChem provides custom synthesis services for Donepezil and related compounds. Contact us with your specific requirements including quantity, purity, and timeline.