topotecan
TL;DR: topotecan (CAS 123948-87-8) is a chemical compound with molecular formula C23H23N3O5 and molecular weight 421.16376 g/mol, supplied by CoreyChem (Career Henan Chemical Co., Ltd.) with ISO-certified quality and global shipping.
8-[(dimethylamino)methyl]-19-ethyl-7,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaene-14,18-dione
Also Known As: topotecan, Topotecan-d6, Topotecan-d5, Topotecan Hcl, Hycamtin;
Application Areas
Top 5 of 2 IPC patent classification(s) from the SureChEMBL global patent database.
Technical Specifications
| Molecular Formula | C23H23N3O5 |
| Molecular Weight | 421.16376 g/mol |
| XLogP | 0.5 |
| Topological Polar Surface Area (TPSA) | 103.0 Ų |
| Hydrogen Bond Donors | 2 |
| Hydrogen Bond Acceptors | 7 |
| Rotatable Bonds | 3 |
| Exact Mass | 421.16376 Da |
| Heavy Atoms | 31 |
| Complexity | 867.0 |
| SMILES | CCC1(C2=C(COC1=O)C(=O)N3CC4=CC5=C(C=CC(=C5CN(C)C)O)N=C4C3=C2)O |
| InChIKey | UCFGDBYHRUNTLO-UHFFFAOYSA-N |
Product Description
Applications: topotecan is used in pharmaceutical synthesis routes and API production, as well as heterocycle construction in medicinal chemistry and agrochemical discovery. It commonly serves as a versatile building block for organic synthesis. Available from CoreyChem as both catalog item and custom-synthesis project (mg to ton scale), with full analytical documentation (COA, MSDS, HPLC, NMR, MS).
topotecan (CAS 123948-87-8) is a pharmaceutical intermediate with the molecular formula C23H23N3O5 and a molecular weight of 421.16 g/mol. Synonyms include topotecan and Topotecan-d6.
Custom synthesis and full analytical documentation (COA/MSDS) are available from CoreyChem. Request a quotation with your required quantity and purity for current lead time and pricing.
Chemical Property Profile of topotecan
Property Insights of topotecan
The XLogP value of 0.5 suggests moderate lipophilicity, balancing water solubility and membrane permeability for topotecan. The TPSA of 103.0 Ų falls within the moderate polarity range, balancing permeability and solubility for topotecan. Following Lipinski's Rule of Five, topotecan has 2 hydrogen bond donor(s) and 7 hydrogen bond acceptor(s), all within the drug-like range, suggesting favorable oral bioavailability potential.
Frequently Asked Questions
What is the CAS number of topotecan?
The CAS number of topotecan is 123948-87-8.
What is the molecular formula of topotecan?
The molecular formula of topotecan is C23H23N3O5.
What is the molecular weight of topotecan?
The molecular weight of topotecan is 421.16376 g/mol.
What are the applications of topotecan?
topotecan is used in pharmaceutical synthesis routes and API production, as well as heterocycle construction in medicinal chemistry and agrochemical discovery. It commonly serves as a versatile building block for organic synthesis. Available from CoreyChem as both catalog item and...
Where can I buy topotecan?
You can request a quote for topotecan directly from CoreyChem. Contact us or email [email protected] for pricing and availability.
Does CoreyChem offer custom synthesis for topotecan?
Yes, CoreyChem provides custom synthesis services for topotecan and related compounds. Contact us with your specific requirements including quantity, purity, and timeline.