Protopine
TL;DR: Protopine (CAS 130-86-9) is a chemical compound with molecular formula C20H19NO5 and molecular weight 353.1263 g/mol, supplied by CoreyChem (Career Henan Chemical Co., Ltd.) with ISO-certified quality and global shipping.
15-methyl-7,9,19,21-tetraoxa-15-azapentacyclo[15.7.0.04,12.06,10.018,22]tetracosa-1(17),4,6(10),11,18(22),23-hexaen-3-one
Also Known As: protopine, Corydinine, Biflorine, Macleyine, Fumarine
Application Areas
Top 5 of 14 IPC patent classification(s) from the SureChEMBL global patent database.
Technical Specifications
| Molecular Formula | C20H19NO5 |
| Molecular Weight | 353.1263 g/mol |
| XLogP | 2.8 |
| Topological Polar Surface Area (TPSA) | 57.2 Ų |
| Hydrogen Bond Donors | 0 |
| Hydrogen Bond Acceptors | 6 |
| Rotatable Bonds | 0 |
| Exact Mass | 353.1263 Da |
| Heavy Atoms | 26 |
| Complexity | 542.0 |
| Melting Point | 208 °C |
| Density | 1.399 (calc) |
| Solubility | Practically insoluble in water |
| SMILES | CN1CCC2=CC3=C(C=C2C(=O)CC4=C(C1)C5=C(C=C4)OCO5)OCO3 |
| InChIKey | GPTFURBXHJWNHR-UHFFFAOYSA-N |
Product Description
Applications: Protopine is used in pharmaceutical synthesis routes and API production, as well as heterocycle construction in medicinal chemistry and agrochemical discovery. It commonly serves as a versatile building block for organic synthesis. Available from CoreyChem as both catalog item and custom-synthesis project (mg to ton scale), with full analytical documentation (COA, MSDS, HPLC, NMR, MS).
A pharmaceutical intermediate supplied by CoreyChem, Protopine (CAS 130-86-9) has the molecular formula C20H19NO5 and a molecular weight of 353.13 g/mol. Reported properties include a density of 1.399 (calc) g/cm³, a solubility: Practically insoluble in water. Synonyms include protopine and Corydinine.
Custom synthesis and full analytical documentation (COA/MSDS) are available from CoreyChem. Request a quotation with your required quantity and purity for current lead time and pricing.
Chemical Property Profile of Protopine
Property Insights of Protopine
The XLogP value of 2.8 suggests moderate lipophilicity, balancing water solubility and membrane permeability for Protopine. With a topological polar surface area (TPSA) of 57.2 Ų, Protopine exhibits relatively low polarity, potentially indicating favorable cell membrane permeability. Following Lipinski's Rule of Five, Protopine has 0 hydrogen bond donor(s) and 6 hydrogen bond acceptor(s), all within the drug-like range, suggesting favorable oral bioavailability potential.
Frequently Asked Questions
What is the CAS number of Protopine?
The CAS number of Protopine is 130-86-9.
What is the molecular formula of Protopine?
The molecular formula of Protopine is C20H19NO5.
What is the molecular weight of Protopine?
The molecular weight of Protopine is 353.1263 g/mol.
What are the applications of Protopine?
Protopine is used in pharmaceutical synthesis routes and API production, as well as heterocycle construction in medicinal chemistry and agrochemical discovery. It commonly serves as a versatile building block for organic synthesis. Available from CoreyChem as both catalog item and...
Where can I buy Protopine?
You can request a quote for Protopine directly from CoreyChem. Contact us or email [email protected] for pricing and availability.
Does CoreyChem offer custom synthesis for Protopine?
Yes, CoreyChem provides custom synthesis services for Protopine and related compounds. Contact us with your specific requirements including quantity, purity, and timeline.