(Trimethylsilyl)imidazole
TL;DR: (Trimethylsilyl)imidazole (CAS 18156-74-6) is a chemical compound with molecular formula C6H12N2Si and molecular weight 140.07698 g/mol, supplied by CoreyChem (Career Henan Chemical Co., Ltd.) with ISO-certified quality and global shipping.
imidazol-1-yl(trimethyl)silane
Also Known As: N-(Trimethylsilyl)imidazole, 1-(Trimethylsilyl)imidazole, 1-(Trimethylsilyl)-1H-imidazole, N-Trimethylsilylimidazole, TSIM
Application Areas
Top 5 of 21 IPC patent classification(s) from the SureChEMBL global patent database.
Technical Specifications
| Molecular Formula | C6H12N2Si |
| Molecular Weight | 140.07698 g/mol |
| XLogP | 1.57 |
| Topological Polar Surface Area (TPSA) | 17.8 Ų |
| Hydrogen Bond Donors | 0 |
| Hydrogen Bond Acceptors | 1 |
| Rotatable Bonds | 1 |
| Exact Mass | 140.07698 Da |
| Heavy Atoms | 9 |
| Complexity | 97.0 |
| Solubility | 14.6 [ug/mL] (The mean of the results at pH 7.4) |
| SMILES | C[Si](C)(C)N1C=CN=C1 |
| InChIKey | YKFRUJSEPGHZFJ-UHFFFAOYSA-N |
Packaging: Sample packaging: 25g / 100g / 500g / 1kg foil pouches. Special products may require customized packaging — confirmed per inquiry.
Lead Time: Most products are manufactured to order; in-stock items are limited. Lead time varies by product — typically weeks to months — and is confirmed per inquiry.
Product Description
Applications: (Trimethylsilyl)imidazole is used in heterocycle construction in medicinal chemistry and agrochemical discovery, as well as pharmaceutical synthesis routes and API production. It commonly serves as a versatile building block for organic synthesis. Available from CoreyChem as both catalog item and custom-synthesis project (mg to ton scale), with full analytical documentation (COA, MSDS, HPLC, NMR, MS).
A heterocyclic building block supplied by CoreyChem, (Trimethylsilyl)imidazole (CAS 18156-74-6) has the molecular formula C6H12N2Si and a molecular weight of 140.08 g/mol. Reported properties include a solubility: 14.6 [ug/mL] (The mean of the results at pH 7.4). Synonyms include N-(Trimethylsilyl)imidazole and 1-(Trimethylsilyl)imidazole.
Custom synthesis and full analytical documentation (COA/MSDS) are available from CoreyChem. Request a quotation with your required quantity and purity for current lead time and pricing.
Chemical Property Profile of (Trimethylsilyl)imidazole
Property Insights of (Trimethylsilyl)imidazole
The XLogP value of 1.57 suggests moderate lipophilicity, balancing water solubility and membrane permeability for (Trimethylsilyl)imidazole. With a topological polar surface area (TPSA) of 17.8 Ų, (Trimethylsilyl)imidazole exhibits relatively low polarity, potentially indicating favorable cell membrane permeability. Following Lipinski's Rule of Five, (Trimethylsilyl)imidazole has 0 hydrogen bond donor(s) and 1 hydrogen bond acceptor(s), all within the drug-like range, suggesting favorable oral bioavailability potential.
Frequently Asked Questions
What is the CAS number of (Trimethylsilyl)imidazole?
The CAS number of (Trimethylsilyl)imidazole is 18156-74-6.
What is the molecular formula of (Trimethylsilyl)imidazole?
The molecular formula of (Trimethylsilyl)imidazole is C6H12N2Si.
What is the molecular weight of (Trimethylsilyl)imidazole?
The molecular weight of (Trimethylsilyl)imidazole is 140.07698 g/mol.
What are the applications of (Trimethylsilyl)imidazole?
(Trimethylsilyl)imidazole is used in heterocycle construction in medicinal chemistry and agrochemical discovery, as well as pharmaceutical synthesis routes and API production. It commonly serves as a versatile building block for organic synthesis. Available from CoreyChem as both catalog item...
Where can I buy (Trimethylsilyl)imidazole?
You can request a quote for (Trimethylsilyl)imidazole directly from CoreyChem. Contact us or email [email protected] for pricing and availability.
Does CoreyChem offer custom synthesis for (Trimethylsilyl)imidazole?
Yes, CoreyChem provides custom synthesis services for (Trimethylsilyl)imidazole and related compounds. Contact us with your specific requirements including quantity, purity, and timeline.