Hexamethyldisilazane
TL;DR: Hexamethyldisilazane (CAS 999-97-3) is a chemical compound with molecular formula C6H19NSi2 and molecular weight 161.1056 g/mol, supplied by CoreyChem (Career Henan Chemical Co., Ltd.) with ISO-certified quality and global shipping.
[dimethyl-(trimethylsilylamino)silyl]methane
Also Known As: Hexamethyldisilazane, HMDS, Bis(trimethylsilyl)amine, Hexamethylsilazane, 1,1,1,3,3,3-Hexamethyldisilazane
Application Areas
Top 5 of 22 IPC patent classification(s) from the SureChEMBL global patent database.
Technical Specifications
| Molecular Formula | C6H19NSi2 |
| Molecular Weight | 161.1056 g/mol |
| XLogP | 2.25 |
| Topological Polar Surface Area (TPSA) | 12.0 Ų |
| Hydrogen Bond Donors | 1 |
| Hydrogen Bond Acceptors | 1 |
| Rotatable Bonds | 2 |
| Exact Mass | 161.1056 Da |
| Heavy Atoms | 9 |
| Complexity | 76.0 |
| Boiling Point | 125 °C |
| Density | 0.7741 g/cu cm at 25 °C |
| Flash Point | 48 °F (NFPA, 2010) |
| Vapor Pressure | 13.8 [mmHg] |
| Refractive Index | Index of refraction = 1.4090 @ 20 °C |
| Solubility | Soluble in acetone, benzene, ethyl ether, heptane, perchloroethylene |
| SMILES | C[Si](C)(C)N[Si](C)(C)C |
| InChIKey | FFUAGWLWBBFQJT-UHFFFAOYSA-N |
Packaging: Sample packaging: 25g / 100g / 500g / 1kg foil pouches. Special products may require customized packaging — confirmed per inquiry.
Lead Time: Most products are manufactured to order; in-stock items are limited. Lead time varies by product — typically weeks to months — and is confirmed per inquiry.
Product Description
Applications: Hexamethyldisilazane is used in heterocycle construction in medicinal chemistry and agrochemical discovery, as well as pharmaceutical synthesis routes and API production. It commonly serves as a versatile building block for organic synthesis. CoreyChem supplies Hexamethyldisilazane (CAS 999-97-3) with custom synthesis available from milligram to multi-kilogram scale, supported by COA, MSDS, and HPLC/NMR/MS documentation.
Hexamethyldisilazane (CAS 999-97-3) is a heterocyclic building block with the molecular formula C6H19NSi2 and a molecular weight of 161.11 g/mol. Key physical properties include a density of 0.7741 g/cu cm at 25 °C g/cm³, a solubility: Soluble in acetone, benzene, ethyl ether, heptane, perchloroethylene. It is also known as Hexamethyldisilazane and HMDS.
Custom synthesis and full analytical documentation (COA/MSDS) are available from CoreyChem. Request a quotation with your required quantity and purity for current lead time and pricing.
Chemical Property Profile of Hexamethyldisilazane
Property Insights of Hexamethyldisilazane
The XLogP value of 2.25 suggests moderate lipophilicity, balancing water solubility and membrane permeability for Hexamethyldisilazane. With a topological polar surface area (TPSA) of 12.0 Ų, Hexamethyldisilazane exhibits relatively low polarity, potentially indicating favorable cell membrane permeability. Following Lipinski's Rule of Five, Hexamethyldisilazane has 1 hydrogen bond donor(s) and 1 hydrogen bond acceptor(s), all within the drug-like range, suggesting favorable oral bioavailability potential.
Frequently Asked Questions
What is the CAS number of Hexamethyldisilazane?
The CAS number of Hexamethyldisilazane is 999-97-3.
What is the molecular formula of Hexamethyldisilazane?
The molecular formula of Hexamethyldisilazane is C6H19NSi2.
What is the molecular weight of Hexamethyldisilazane?
The molecular weight of Hexamethyldisilazane is 161.1056 g/mol.
What are the applications of Hexamethyldisilazane?
Hexamethyldisilazane is used in heterocycle construction in medicinal chemistry and agrochemical discovery, as well as pharmaceutical synthesis routes and API production. It commonly serves as a versatile building block for organic synthesis. CoreyChem supplies Hexamethyldisilazane (CAS...
Where can I buy Hexamethyldisilazane?
You can request a quote for Hexamethyldisilazane directly from CoreyChem. Contact us or email [email protected] for pricing and availability.
Does CoreyChem offer custom synthesis for Hexamethyldisilazane?
Yes, CoreyChem provides custom synthesis services for Hexamethyldisilazane and related compounds. Contact us with your specific requirements including quantity, purity, and timeline.