Nifedipine
TL;DR: Nifedipine (CAS 21829-25-4) is a chemical compound with molecular formula C17H18N2O6 and molecular weight 346.1165 g/mol, supplied by CoreyChem (Career Henan Chemical Co., Ltd.) with ISO-certified quality and global shipping.
dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
Also Known As: nifedipine, Procardia, Adalat, Cordipin, Corinfar
Application Areas
Top 5 of 21 IPC patent classification(s) from the SureChEMBL global patent database.
Technical Specifications
| Molecular Formula | C17H18N2O6 |
| Molecular Weight | 346.1165 g/mol |
| XLogP | 2.2 |
| Topological Polar Surface Area (TPSA) | 110.0 Ų |
| Hydrogen Bond Donors | 1 |
| Hydrogen Bond Acceptors | 7 |
| Rotatable Bonds | 5 |
| Exact Mass | 346.1165 Da |
| Heavy Atoms | 25 |
| Complexity | 608.0 |
| Melting Point | 342 to 345 °F (NTP, 1992) |
| Vapor Pressure | 2.6X10-8 mm Hg at 25 °C |
| Solubility | less than 1 mg/mL at 67.1 °F (NTP, 1992) |
| SMILES | CC1=C(C(C(=C(N1)C)C(=O)OC)C2=CC=CC=C2[N+](=O)[O-])C(=O)OC |
| InChIKey | HYIMSNHJOBLJNT-UHFFFAOYSA-N |
Product Description
Applications: Nifedipine is used in pharmaceutical synthesis routes and API production, as well as heterocycle construction in medicinal chemistry and agrochemical discovery. It commonly serves as a versatile building block for organic synthesis. Available from CoreyChem as both catalog item and custom-synthesis project (mg to ton scale), with full analytical documentation (COA, MSDS, HPLC, NMR, MS).
Nifedipine is a pharmaceutical intermediate identified by CAS number 21829-25-4 and the molecular formula C17H18N2O6 and a molecular weight of 346.12 g/mol. Physically, the compound has a solubility: less than 1 mg/mL at 67.1 °F (NTP, 1992). Synonyms include nifedipine and Procardia.
Custom synthesis and full analytical documentation (COA/MSDS) are available from CoreyChem. Request a quotation with your required quantity and purity for current lead time and pricing.
Chemical Property Profile of Nifedipine
Property Insights of Nifedipine
The XLogP value of 2.2 suggests moderate lipophilicity, balancing water solubility and membrane permeability for Nifedipine. The TPSA of 110.0 Ų falls within the moderate polarity range, balancing permeability and solubility for Nifedipine. Following Lipinski's Rule of Five, Nifedipine has 1 hydrogen bond donor(s) and 7 hydrogen bond acceptor(s), all within the drug-like range, suggesting favorable oral bioavailability potential.
Frequently Asked Questions
What is the CAS number of Nifedipine?
The CAS number of Nifedipine is 21829-25-4.
What is the molecular formula of Nifedipine?
The molecular formula of Nifedipine is C17H18N2O6.
What is the molecular weight of Nifedipine?
The molecular weight of Nifedipine is 346.1165 g/mol.
What are the applications of Nifedipine?
Nifedipine is used in pharmaceutical synthesis routes and API production, as well as heterocycle construction in medicinal chemistry and agrochemical discovery. It commonly serves as a versatile building block for organic synthesis. Available from CoreyChem as both catalog item and...
Where can I buy Nifedipine?
You can request a quote for Nifedipine directly from CoreyChem. Contact us or email [email protected] for pricing and availability.
Does CoreyChem offer custom synthesis for Nifedipine?
Yes, CoreyChem provides custom synthesis services for Nifedipine and related compounds. Contact us with your specific requirements including quantity, purity, and timeline.