(-)-Menthol
TL;DR: (-)-Menthol (CAS 2216-51-5) is a chemical compound with molecular formula C10H20O and molecular weight 156.15141 g/mol, supplied by CoreyChem (Career Henan Chemical Co., Ltd.) with ISO-certified quality and global shipping.
(1R,2S,5R)-5-methyl-2-propan-2-ylcyclohexan-1-ol
Also Known As: l-Menthol, (-)-menthol, Levomenthol, dl-Menthol, MENTHOL
Application Areas
Top 5 of 22 IPC patent classification(s) from the SureChEMBL global patent database.
Technical Specifications
| Molecular Formula | C10H20O |
| Molecular Weight | 156.15141 g/mol |
| XLogP | 3.0 |
| Topological Polar Surface Area (TPSA) | 20.2 Ų |
| Hydrogen Bond Donors | 1 |
| Hydrogen Bond Acceptors | 1 |
| Rotatable Bonds | 1 |
| Exact Mass | 156.15141 Da |
| Heavy Atoms | 11 |
| Complexity | 120.0 |
| Purity | ≥99% |
| Melting Point | 100 °F (NTP, 1992) |
| Boiling Point | 421 °F at 760 mmHg (NTP, 1992) |
| Density | 0.904 at 59 °F (NTP, 1992) - Less dense than water; will float |
| Flash Point | 196 °F (NTP, 1992) |
| Vapor Pressure | 1 mmHg at 133 °F approximately (NTP, 1992) |
| Refractive Index | SPECIFIC OPTICAL ROTATION: -50 DEG (10% ALCOHOL SOLN) @ 18 °C/D; INDEX OF REFRACTION: 1.458 @ 25 °C/D |
| Solubility | less than 1 mg/mL at 70 °F (NTP, 1992) |
| SMILES | C[C@@H]1CC[C@H]([C@@H](C1)O)C(C)C |
| InChIKey | NOOLISFMXDJSKH-KXUCPTDWSA-N |
Product Description
Applications: (-)-Menthol is used in pharmaceutical synthesis routes and API production, as well as heterocycle construction in medicinal chemistry and agrochemical discovery. It commonly serves as a versatile building block for organic synthesis. Typical specifications: commercial lots are supplied at ≥99%. CoreyChem supplies (-)-Menthol (CAS 2216-51-5) with custom synthesis available from milligram to multi-kilogram scale, supported by COA, MSDS, and HPLC/NMR/MS documentation.
(-)-Menthol is a pharmaceutical intermediate identified by CAS number 2216-51-5 and the molecular formula C10H20O and a molecular weight of 156.15 g/mol. Physically, the compound has a density of 0.904 at 59 °F (NTP, 1992) - Less dense than water; will float g/cm³, a solubility: less than 1 mg/mL at 70 °F (NTP, 1992). It is also known as l-Menthol and (-)-menthol.
CoreyChem provides it with COA documentation, and custom synthesis from milligram to multi-kilogram scales is available on request. Request a quotation with your required quantity and purity for current lead time and pricing.
Safety Information
H315, H319
Chemical Property Profile of (-)-Menthol
Property Insights of (-)-Menthol
The XLogP value of 3.0 indicates that (-)-Menthol is lipophilic (fat-soluble), which may influence its absorption, distribution, and formulation strategy. With a topological polar surface area (TPSA) of 20.2 Ų, (-)-Menthol exhibits relatively low polarity, potentially indicating favorable cell membrane permeability. Following Lipinski's Rule of Five, (-)-Menthol has 1 hydrogen bond donor(s) and 1 hydrogen bond acceptor(s), all within the drug-like range, suggesting favorable oral bioavailability potential.
Frequently Asked Questions
What is the CAS number of (-)-Menthol?
The CAS number of (-)-Menthol is 2216-51-5.
What is the molecular formula of (-)-Menthol?
The molecular formula of (-)-Menthol is C10H20O.
What is the molecular weight of (-)-Menthol?
The molecular weight of (-)-Menthol is 156.15141 g/mol.
What are the applications of (-)-Menthol?
(-)-Menthol is used in pharmaceutical synthesis routes and API production, as well as heterocycle construction in medicinal chemistry and agrochemical discovery. It commonly serves as a versatile building block for organic synthesis. Typical specifications: commercial lots are supplied at ≥99%....
Where can I buy (-)-Menthol?
You can request a quote for (-)-Menthol directly from CoreyChem. Contact us or email [email protected] for pricing and availability.
Does CoreyChem offer custom synthesis for (-)-Menthol?
Yes, CoreyChem provides custom synthesis services for (-)-Menthol and related compounds. Contact us with your specific requirements including quantity, purity, and timeline.