2,4-Difluoroaniline
TL;DR: 2,4-Difluoroaniline (CAS 367-25-9) is a chemical compound with molecular formula C6H5F2N and molecular weight 129.039 g/mol, supplied by CoreyChem (Career Henan Chemical Co., Ltd.) with ISO-certified quality and global shipping.
2,4-difluoroaniline
Also Known As: 2,4-DIFLUOROANILINE, 2,4-Difluorobenzenamine, Benzenamine, 2,4-difluoro-, 2,4-Difluroaniline, Paullone
Application Areas
Top 5 of 14 IPC patent classification(s) from the SureChEMBL global patent database.
Technical Specifications
| Molecular Formula | C6H5F2N |
| Molecular Weight | 129.039 g/mol |
| XLogP | 1.5 |
| Topological Polar Surface Area (TPSA) | 26.0 Ų |
| Hydrogen Bond Donors | 1 |
| Hydrogen Bond Acceptors | 3 |
| Rotatable Bonds | 0 |
| Exact Mass | 129.039 Da |
| Heavy Atoms | 9 |
| Complexity | 97.0 |
| Melting Point | 18.5 °F (NTP, 1992) |
| Boiling Point | 338 °F at 753 mmHg (NTP, 1992) |
| Density | 1.268 (NTP, 1992) - Denser than water; will sink |
| Flash Point | 145 °F (NTP, 1992) |
| Solubility | 10 to 50 mg/mL at 68.9 °F (NTP, 1992) |
| SMILES | C1=CC(=C(C=C1F)F)N |
| InChIKey | CEPCPXLLFXPZGW-UHFFFAOYSA-N |
Product Description
Applications: 2,4-Difluoroaniline is used in heterocycle construction in medicinal chemistry and agrochemical discovery, as well as pharmaceutical synthesis routes and API production. It commonly serves as a versatile building block for organic synthesis. CoreyChem supplies 2,4-Difluoroaniline (CAS 367-25-9) with custom synthesis available from milligram to multi-kilogram scale, supported by COA, MSDS, and HPLC/NMR/MS documentation.
A heterocyclic building block supplied by CoreyChem, 2,4-Difluoroaniline (CAS 367-25-9) has the molecular formula C6H5F2N and a molecular weight of 129.04 g/mol. Reported properties include a density of 1.268 (NTP, 1992) - Denser than water; will sink g/cm³, a solubility: 10 to 50 mg/mL at 68.9 °F (NTP, 1992). It is also known as 2,4-DIFLUOROANILINE and 2,4-Difluorobenzenamine.
Custom synthesis and full analytical documentation (COA/MSDS) are available from CoreyChem. Request a quotation with your required quantity and purity for current lead time and pricing.
Chemical Property Profile of 2,4-Difluoroaniline
Property Insights of 2,4-Difluoroaniline
The XLogP value of 1.5 suggests moderate lipophilicity, balancing water solubility and membrane permeability for 2,4-Difluoroaniline. With a topological polar surface area (TPSA) of 26.0 Ų, 2,4-Difluoroaniline exhibits relatively low polarity, potentially indicating favorable cell membrane permeability. Following Lipinski's Rule of Five, 2,4-Difluoroaniline has 1 hydrogen bond donor(s) and 3 hydrogen bond acceptor(s), all within the drug-like range, suggesting favorable oral bioavailability potential.
Frequently Asked Questions
What is the CAS number of 2,4-Difluoroaniline?
The CAS number of 2,4-Difluoroaniline is 367-25-9.
What is the molecular formula of 2,4-Difluoroaniline?
The molecular formula of 2,4-Difluoroaniline is C6H5F2N.
What is the molecular weight of 2,4-Difluoroaniline?
The molecular weight of 2,4-Difluoroaniline is 129.039 g/mol.
What are the applications of 2,4-Difluoroaniline?
2,4-Difluoroaniline is used in heterocycle construction in medicinal chemistry and agrochemical discovery, as well as pharmaceutical synthesis routes and API production. It commonly serves as a versatile building block for organic synthesis. CoreyChem supplies 2,4-Difluoroaniline (CAS 367-25-9)...
Where can I buy 2,4-Difluoroaniline?
You can request a quote for 2,4-Difluoroaniline directly from CoreyChem. Contact us or email [email protected] for pricing and availability.
Does CoreyChem offer custom synthesis for 2,4-Difluoroaniline?
Yes, CoreyChem provides custom synthesis services for 2,4-Difluoroaniline and related compounds. Contact us with your specific requirements including quantity, purity, and timeline.