Verapamil
TL;DR: Verapamil (CAS 52-53-9) is a chemical compound with molecular formula C27H38N2O4 and molecular weight 454.28317 g/mol, supplied by CoreyChem (Career Henan Chemical Co., Ltd.) with ISO-certified quality and global shipping.
2-(3,4-dimethoxyphenyl)-5-[2-(3,4-dimethoxyphenyl)ethyl-methylamino]-2-propan-2-ylpentanenitrile
Also Known As: VERAPAMIL, Iproveratril, Dilacoran, Vasolan, Verapamilo
Application Areas
Top 5 of 19 IPC patent classification(s) from the SureChEMBL global patent database.
Technical Specifications
| Molecular Formula | C27H38N2O4 |
| Molecular Weight | 454.28317 g/mol |
| XLogP | 3.8 |
| Topological Polar Surface Area (TPSA) | 64.0 Ų |
| Hydrogen Bond Donors | 0 |
| Hydrogen Bond Acceptors | 6 |
| Rotatable Bonds | 13 |
| Exact Mass | 454.28317 Da |
| Heavy Atoms | 33 |
| Complexity | 606.0 |
| Melting Point | < 25 °C |
| Boiling Point | BP: 245 °C at 0.01 mm Hg |
| Refractive Index | Index of refraction: 1.5448 at 25 °C |
| Solubility | Solubility (mg/mL): water 83, ethanol (200 proof) 26, propylene glycol 93, ethanol (190 proof) >100, methanol >100, 2-propanol 4.6, ethyl acetate 1.0, DMF >100, methylene chloride >100, hexane 0.001; Freely soluble in chloroform, practically insoluble in ether /Verapamil hydrochloride/ |
| SMILES | CC(C)C(CCCN(C)CCC1=CC(=C(C=C1)OC)OC)(C#N)C2=CC(=C(C=C2)OC)OC |
| InChIKey | SGTNSNPWRIOYBX-UHFFFAOYSA-N |
Product Description
Applications: Verapamil is used in pharmaceutical synthesis routes and API production, as well as heterocycle construction in medicinal chemistry and agrochemical discovery. It commonly serves as a versatile building block for organic synthesis. Available from CoreyChem as both catalog item and custom-synthesis project (mg to ton scale), with full analytical documentation (COA, MSDS, HPLC, NMR, MS).
Verapamil (CAS 52-53-9) is a pharmaceutical intermediate with the molecular formula C27H38N2O4 and a molecular weight of 454.28 g/mol. Key physical properties include a solubility: Solubility (mg/mL): water 83, ethanol (200 proof) 26, propylene glycol 93, ethanol (190 proof) >100, methanol >100, 2-propanol 4.6, ethyl acetate 1.0, DMF >100, methylene chloride >100, hexane 0.001; Freely soluble in chloroform, practically insoluble in ether /Verapamil hydrochloride/. Synonyms include VERAPAMIL and Iproveratril.
Custom synthesis and full analytical documentation (COA/MSDS) are available from CoreyChem. Request a quotation with your required quantity and purity for current lead time and pricing.
Chemical Property Profile of Verapamil
Property Insights of Verapamil
The XLogP value of 3.8 indicates that Verapamil is lipophilic (fat-soluble), which may influence its absorption, distribution, and formulation strategy. The TPSA of 64.0 Ų falls within the moderate polarity range, balancing permeability and solubility for Verapamil. Following Lipinski's Rule of Five, Verapamil has 0 hydrogen bond donor(s) and 6 hydrogen bond acceptor(s), all within the drug-like range, suggesting favorable oral bioavailability potential.
Frequently Asked Questions
What is the CAS number of Verapamil?
The CAS number of Verapamil is 52-53-9.
What is the molecular formula of Verapamil?
The molecular formula of Verapamil is C27H38N2O4.
What is the molecular weight of Verapamil?
The molecular weight of Verapamil is 454.28317 g/mol.
What are the applications of Verapamil?
Verapamil is used in pharmaceutical synthesis routes and API production, as well as heterocycle construction in medicinal chemistry and agrochemical discovery. It commonly serves as a versatile building block for organic synthesis. Available from CoreyChem as both catalog item and...
Where can I buy Verapamil?
You can request a quote for Verapamil directly from CoreyChem. Contact us or email [email protected] for pricing and availability.
Does CoreyChem offer custom synthesis for Verapamil?
Yes, CoreyChem provides custom synthesis services for Verapamil and related compounds. Contact us with your specific requirements including quantity, purity, and timeline.