Trimetrexate
TL;DR: Trimetrexate (CAS 52128-35-5) is a chemical compound with molecular formula C19H23N5O3 and molecular weight 369.18008 g/mol, supplied by CoreyChem (Career Henan Chemical Co., Ltd.) with ISO-certified quality and global shipping.
5-methyl-6-[(3,4,5-trimethoxyanilino)methyl]quinazoline-2,4-diamine
Also Known As: trimetrexate, Trimetrexato, Trimetrexatum, Neutrexin, Trimexate
Application Areas
Top 5 of 14 IPC patent classification(s) from the SureChEMBL global patent database.
Technical Specifications
| Molecular Formula | C19H23N5O3 |
| Molecular Weight | 369.18008 g/mol |
| XLogP | 2.5 |
| Topological Polar Surface Area (TPSA) | 118.0 Ų |
| Hydrogen Bond Donors | 3 |
| Hydrogen Bond Acceptors | 8 |
| Rotatable Bonds | 6 |
| Exact Mass | 369.18008 Da |
| Heavy Atoms | 27 |
| Complexity | 457.0 |
| Melting Point | 215-217 °C |
| Solubility | 31.4 |
| SMILES | CC1=C(C=CC2=C1C(=NC(=N2)N)N)CNC3=CC(=C(C(=C3)OC)OC)OC |
| InChIKey | NOYPYLRCIDNJJB-UHFFFAOYSA-N |
Product Description
Applications: Trimetrexate is used in pharmaceutical synthesis routes and API production, as well as heterocycle construction in medicinal chemistry and agrochemical discovery. It commonly serves as a versatile building block for organic synthesis. CoreyChem supplies Trimetrexate (CAS 52128-35-5) with custom synthesis available from milligram to multi-kilogram scale, supported by COA, MSDS, and HPLC/NMR/MS documentation.
A pharmaceutical intermediate supplied by CoreyChem, Trimetrexate (CAS 52128-35-5) has the molecular formula C19H23N5O3 and a molecular weight of 369.18 g/mol. Reported properties include a solubility: 31.4. It is also known as trimetrexate and Trimetrexato.
Custom synthesis and full analytical documentation (COA/MSDS) are available from CoreyChem. Request a quotation with your required quantity and purity for current lead time and pricing.
Chemical Property Profile of Trimetrexate
Property Insights of Trimetrexate
The XLogP value of 2.5 suggests moderate lipophilicity, balancing water solubility and membrane permeability for Trimetrexate. The TPSA of 118.0 Ų falls within the moderate polarity range, balancing permeability and solubility for Trimetrexate. Following Lipinski's Rule of Five, Trimetrexate has 3 hydrogen bond donor(s) and 8 hydrogen bond acceptor(s), all within the drug-like range, suggesting favorable oral bioavailability potential.
Frequently Asked Questions
What is the CAS number of Trimetrexate?
The CAS number of Trimetrexate is 52128-35-5.
What is the molecular formula of Trimetrexate?
The molecular formula of Trimetrexate is C19H23N5O3.
What is the molecular weight of Trimetrexate?
The molecular weight of Trimetrexate is 369.18008 g/mol.
What are the applications of Trimetrexate?
Trimetrexate is used in pharmaceutical synthesis routes and API production, as well as heterocycle construction in medicinal chemistry and agrochemical discovery. It commonly serves as a versatile building block for organic synthesis. CoreyChem supplies Trimetrexate (CAS 52128-35-5) with custom...
Where can I buy Trimetrexate?
You can request a quote for Trimetrexate directly from CoreyChem. Contact us or email [email protected] for pricing and availability.
Does CoreyChem offer custom synthesis for Trimetrexate?
Yes, CoreyChem provides custom synthesis services for Trimetrexate and related compounds. Contact us with your specific requirements including quantity, purity, and timeline.