Naftopidil
TL;DR: Naftopidil (CAS 57149-07-2) is a chemical compound with molecular formula C24H28N2O3 and molecular weight 392.21 g/mol, supplied by CoreyChem (Career Henan Chemical Co., Ltd.) with ISO-certified quality and global shipping.
1-[4-(2-methoxyphenyl)piperazin-1-yl]-3-naphthalen-1-yloxypropan-2-ol
Also Known As: naftopidil, Flivas, Avishot, Naftopidilum, Naftopidil [INN]
Application Areas
Top 5 of 9 IPC patent classification(s) from the SureChEMBL global patent database.
Technical Specifications
| Molecular Formula | C24H28N2O3 |
| Molecular Weight | 392.21 g/mol |
| XLogP | 4.1 |
| Topological Polar Surface Area (TPSA) | 45.2 Ų |
| Hydrogen Bond Donors | 1 |
| Hydrogen Bond Acceptors | 5 |
| Rotatable Bonds | 7 |
| Exact Mass | 392.21 Da |
| Heavy Atoms | 29 |
| Complexity | 483.0 |
| SMILES | COC1=CC=CC=C1N2CCN(CC2)CC(COC3=CC=CC4=CC=CC=C43)O |
| InChIKey | HRRBJVNMSRJFHQ-UHFFFAOYSA-N |
Product Description
Applications: Naftopidil is used in pharmaceutical synthesis routes and API production, as well as heterocycle construction in medicinal chemistry and agrochemical discovery. It commonly serves as a versatile building block for organic synthesis. Available from CoreyChem as both catalog item and custom-synthesis project (mg to ton scale), with full analytical documentation (COA, MSDS, HPLC, NMR, MS).
A pharmaceutical intermediate supplied by CoreyChem, Naftopidil (CAS 57149-07-2) has the molecular formula C24H28N2O3 and a molecular weight of 392.21 g/mol. Synonyms include naftopidil and Flivas.
Custom synthesis and full analytical documentation (COA/MSDS) are available from CoreyChem. Request a quotation with your required quantity and purity for current lead time and pricing.
Chemical Property Profile of Naftopidil
Property Insights of Naftopidil
The XLogP value of 4.1 indicates that Naftopidil is lipophilic (fat-soluble), which may influence its absorption, distribution, and formulation strategy. With a topological polar surface area (TPSA) of 45.2 Ų, Naftopidil exhibits relatively low polarity, potentially indicating favorable cell membrane permeability. Following Lipinski's Rule of Five, Naftopidil has 1 hydrogen bond donor(s) and 5 hydrogen bond acceptor(s), all within the drug-like range, suggesting favorable oral bioavailability potential.
Frequently Asked Questions
What is the CAS number of Naftopidil?
The CAS number of Naftopidil is 57149-07-2.
What is the molecular formula of Naftopidil?
The molecular formula of Naftopidil is C24H28N2O3.
What is the molecular weight of Naftopidil?
The molecular weight of Naftopidil is 392.21 g/mol.
What are the applications of Naftopidil?
Naftopidil is used in pharmaceutical synthesis routes and API production, as well as heterocycle construction in medicinal chemistry and agrochemical discovery. It commonly serves as a versatile building block for organic synthesis. Available from CoreyChem as both catalog item and...
Where can I buy Naftopidil?
You can request a quote for Naftopidil directly from CoreyChem. Contact us or email [email protected] for pricing and availability.
Does CoreyChem offer custom synthesis for Naftopidil?
Yes, CoreyChem provides custom synthesis services for Naftopidil and related compounds. Contact us with your specific requirements including quantity, purity, and timeline.