Trimethoprim
TL;DR: Trimethoprim (CAS 738-70-5) is a chemical compound with molecular formula C14H18N4O3 and molecular weight 290.13788 g/mol, supplied by CoreyChem (Career Henan Chemical Co., Ltd.) with ISO-certified quality and global shipping.
5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-diamine
Also Known As: trimethoprim, Proloprim, Trimpex, Trimetoprim, Monotrim
Application Areas
Top 5 of 22 IPC patent classification(s) from the SureChEMBL global patent database.
Technical Specifications
| Molecular Formula | C14H18N4O3 |
| Molecular Weight | 290.13788 g/mol |
| XLogP | 0.9 |
| Topological Polar Surface Area (TPSA) | 106.0 Ų |
| Hydrogen Bond Donors | 2 |
| Hydrogen Bond Acceptors | 7 |
| Rotatable Bonds | 5 |
| Exact Mass | 290.13788 Da |
| Heavy Atoms | 21 |
| Complexity | 307.0 |
| Melting Point | 390 to 397 °F (NTP, 1992) |
| Solubility | less than 1 mg/mL at 75 °F (NTP, 1992) |
| SMILES | COC1=CC(=CC(=C1OC)OC)CC2=CN=C(N=C2N)N |
| InChIKey | IEDVJHCEMCRBQM-UHFFFAOYSA-N |
Product Description
Applications: Trimethoprim is used in pharmaceutical synthesis routes and API production, as well as biotechnology workflows and life-science research. It commonly serves as a versatile building block for organic synthesis. Available from CoreyChem as both catalog item and custom-synthesis project (mg to ton scale), with full analytical documentation (COA, MSDS, HPLC, NMR, MS).
Trimethoprim (CAS 738-70-5) is a pharmaceutical intermediate with the molecular formula C14H18N4O3 and a molecular weight of 290.14 g/mol. Key physical properties include a solubility: less than 1 mg/mL at 75 °F (NTP, 1992). Synonyms include trimethoprim and Proloprim.
Custom synthesis and full analytical documentation (COA/MSDS) are available from CoreyChem. Request a quotation with your required quantity and purity for current lead time and pricing.
Chemical Property Profile of Trimethoprim
Property Insights of Trimethoprim
The XLogP value of 0.9 suggests moderate lipophilicity, balancing water solubility and membrane permeability for Trimethoprim. The TPSA of 106.0 Ų falls within the moderate polarity range, balancing permeability and solubility for Trimethoprim. Following Lipinski's Rule of Five, Trimethoprim has 2 hydrogen bond donor(s) and 7 hydrogen bond acceptor(s), all within the drug-like range, suggesting favorable oral bioavailability potential.
Frequently Asked Questions
What is the CAS number of Trimethoprim?
The CAS number of Trimethoprim is 738-70-5.
What is the molecular formula of Trimethoprim?
The molecular formula of Trimethoprim is C14H18N4O3.
What is the molecular weight of Trimethoprim?
The molecular weight of Trimethoprim is 290.13788 g/mol.
What are the applications of Trimethoprim?
Trimethoprim is used in pharmaceutical synthesis routes and API production, as well as biotechnology workflows and life-science research. It commonly serves as a versatile building block for organic synthesis. Available from CoreyChem as both catalog item and custom-synthesis project (mg to ton...
Where can I buy Trimethoprim?
You can request a quote for Trimethoprim directly from CoreyChem. Contact us or email [email protected] for pricing and availability.
Does CoreyChem offer custom synthesis for Trimethoprim?
Yes, CoreyChem provides custom synthesis services for Trimethoprim and related compounds. Contact us with your specific requirements including quantity, purity, and timeline.