Tris(hydroxymethyl)aminomethane
TL;DR: Tris(hydroxymethyl)aminomethane (CAS 77-86-1) is a chemical compound with molecular formula C4H11NO3 and molecular weight 121.07389 g/mol, supplied by CoreyChem (Career Henan Chemical Co., Ltd.) with ISO-certified quality and global shipping.
2-amino-2-(hydroxymethyl)propane-1,3-diol
Also Known As: Trometamol, TROMETHAMINE, Tris, Tris(Hydroxymethyl)aminomethane, Tham
Application Areas
Top 5 of 22 IPC patent classification(s) from the SureChEMBL global patent database.
Technical Specifications
| Molecular Formula | C4H11NO3 |
| Molecular Weight | 121.07389 g/mol |
| XLogP | -2.9 |
| Topological Polar Surface Area (TPSA) | 86.7 Ų |
| Hydrogen Bond Donors | 4 |
| Hydrogen Bond Acceptors | 4 |
| Rotatable Bonds | 3 |
| Exact Mass | 121.07389 Da |
| Heavy Atoms | 8 |
| Complexity | 54.0 |
| Melting Point | 171-172 °C |
| Boiling Point | 219-220 °C at 10 mm Hg |
| Vapor Pressure | 0.000022 [mmHg] |
| Solubility | 79.1 mg/mL in ethylene glycol; 26 mg/mL in methanol; 14.6 mg/mL in anhyd ethanol; 22 mg/mL in 95% ethanol; 14 mg/mL in dimethyl formamide; 20 mg/mL in acetone; 0.5 mg/mL in ethyl acetate; 0.4 mg/mL in olive oil; 0.1 mg/mL in cyclohexane; 0.05 mg/mL in chloroform; less than 0.05 mg/mL in carbon tetrachloride |
| SMILES | C(C(CO)(CO)N)O |
| InChIKey | LENZDBCJOHFCAS-UHFFFAOYSA-N |
Product Description
Applications: Tris(hydroxymethyl)aminomethane is used in biotechnology workflows and life-science research, as well as pharmaceutical synthesis routes and API production. It commonly serves as a versatile building block for organic synthesis. CoreyChem supplies Tris(hydroxymethyl)aminomethane (CAS 77-86-1) with custom synthesis available from milligram to multi-kilogram scale, supported by COA, MSDS, and HPLC/NMR/MS documentation.
Tris(hydroxymethyl)aminomethane is a biotechnology compound identified by CAS number 77-86-1 and the molecular formula C4H11NO3 and a molecular weight of 121.07 g/mol. Physically, the compound has a solubility: 79.1 mg/mL in ethylene glycol; 26 mg/mL in methanol; 14.6 mg/mL in anhyd ethanol; 22 mg/mL in 95% ethanol; 14 mg/mL in dimethyl formamide; 20 mg/mL in acetone; 0.5 mg/mL in ethyl acetate; 0.4 mg/mL in olive oil; 0.1 mg/mL in cyclohexane; 0.05 mg/mL in chloroform; less than 0.05 mg/mL in carbon tetrachloride. It is also known as Trometamol and TROMETHAMINE.
Custom synthesis and full analytical documentation (COA/MSDS) are available from CoreyChem. Request a quotation with your required quantity and purity for current lead time and pricing.
Chemical Property Profile of Tris(hydroxymethyl)aminomethane
Property Insights of Tris(hydroxymethyl)aminomethane
The XLogP value of -2.9 indicates that Tris(hydroxymethyl)aminomethane is hydrophilic (water-soluble), making it suitable for aqueous formulations and biological assay applications. The TPSA of 86.7 Ų falls within the moderate polarity range, balancing permeability and solubility for Tris(hydroxymethyl)aminomethane. Following Lipinski's Rule of Five, Tris(hydroxymethyl)aminomethane has 4 hydrogen bond donor(s) and 4 hydrogen bond acceptor(s), all within the drug-like range, suggesting favorable oral bioavailability potential.
Frequently Asked Questions
What is the CAS number of Tris(hydroxymethyl)aminomethane?
The CAS number of Tris(hydroxymethyl)aminomethane is 77-86-1.
What is the molecular formula of Tris(hydroxymethyl)aminomethane?
The molecular formula of Tris(hydroxymethyl)aminomethane is C4H11NO3.
What is the molecular weight of Tris(hydroxymethyl)aminomethane?
The molecular weight of Tris(hydroxymethyl)aminomethane is 121.07389 g/mol.
What are the applications of Tris(hydroxymethyl)aminomethane?
Tris(hydroxymethyl)aminomethane is used in biotechnology workflows and life-science research, as well as pharmaceutical synthesis routes and API production. It commonly serves as a versatile building block for organic synthesis. CoreyChem supplies Tris(hydroxymethyl)aminomethane (CAS 77-86-1)...
Where can I buy Tris(hydroxymethyl)aminomethane?
You can request a quote for Tris(hydroxymethyl)aminomethane directly from CoreyChem. Contact us or email [email protected] for pricing and availability.
Does CoreyChem offer custom synthesis for Tris(hydroxymethyl)aminomethane?
Yes, CoreyChem provides custom synthesis services for Tris(hydroxymethyl)aminomethane and related compounds. Contact us with your specific requirements including quantity, purity, and timeline.