N,N-Bis(trimethylsilyl)trifluoroacetamide
TL;DR: N,N-Bis(trimethylsilyl)trifluoroacetamide (CAS 21149-38-2) is a chemical compound with molecular formula C8H18F3NOSi2 and molecular weight 257.0879 g/mol, supplied by CoreyChem (Career Henan Chemical Co., Ltd.) with ISO-certified quality and global shipping.
2,2,2-trifluoro-N,N-bis(trimethylsilyl)acetamide
Also Known As: Bis(trimethylsilyl)trifluoroacetamide, 2,2,2-Trifluoro-N,N-bis(trimethylsilyl)acetamide, Acetamide, 2,2,2-trifluoro-N,N-bis(trimethylsilyl)-, N,N-BSTFA, Bis(trimethylsilyl)sulfate
Application Areas
Top 5 of 20 IPC patent classification(s) from the SureChEMBL global patent database.
Technical Specifications
| Molecular Formula | C8H18F3NOSi2 |
| Molecular Weight | 257.0879 g/mol |
| XLogP | 3.05 |
| Topological Polar Surface Area (TPSA) | 20.3 Ų |
| Hydrogen Bond Donors | 0 |
| Hydrogen Bond Acceptors | 4 |
| Rotatable Bonds | 2 |
| Exact Mass | 257.0879 Da |
| Heavy Atoms | 15 |
| Complexity | 238.0 |
| SMILES | C[Si](C)(C)N(C(=O)C(F)(F)F)[Si](C)(C)C |
| InChIKey | RZYHXKLKJRGJGP-UHFFFAOYSA-N |
Product Description
Applications: N,N-Bis(trimethylsilyl)trifluoroacetamide is used in heterocycle construction in medicinal chemistry and agrochemical discovery, as well as pharmaceutical synthesis routes and API production. It commonly serves as a versatile building block for organic synthesis. Available from CoreyChem as both catalog item and custom-synthesis project (mg to ton scale), with full analytical documentation (COA, MSDS, HPLC, NMR, MS).
A heterocyclic building block supplied by CoreyChem, N,N-Bis(trimethylsilyl)trifluoroacetamide (CAS 21149-38-2) has the molecular formula C8H18F3NOSi2 and a molecular weight of 257.09 g/mol. Synonyms include Bis(trimethylsilyl)trifluoroacetamide and 2,2,2-Trifluoro-N,N-bis(trimethylsilyl)acetamide.
Custom synthesis and full analytical documentation (COA/MSDS) are available from CoreyChem. Request a quotation with your required quantity and purity for current lead time and pricing.
Chemical Property Profile of N,N-Bis(trimethylsilyl)trifluoroacetamide
Property Insights of N,N-Bis(trimethylsilyl)trifluoroacetamide
The XLogP value of 3.05 indicates that N,N-Bis(trimethylsilyl)trifluoroacetamide is lipophilic (fat-soluble), which may influence its absorption, distribution, and formulation strategy. With a topological polar surface area (TPSA) of 20.3 Ų, N,N-Bis(trimethylsilyl)trifluoroacetamide exhibits relatively low polarity, potentially indicating favorable cell membrane permeability. Following Lipinski's Rule of Five, N,N-Bis(trimethylsilyl)trifluoroacetamide has 0 hydrogen bond donor(s) and 4 hydrogen bond acceptor(s), all within the drug-like range, suggesting favorable oral bioavailability potential.
Frequently Asked Questions
What is the CAS number of N,N-Bis(trimethylsilyl)trifluoroacetamide?
The CAS number of N,N-Bis(trimethylsilyl)trifluoroacetamide is 21149-38-2.
What is the molecular formula of N,N-Bis(trimethylsilyl)trifluoroacetamide?
The molecular formula of N,N-Bis(trimethylsilyl)trifluoroacetamide is C8H18F3NOSi2.
What is the molecular weight of N,N-Bis(trimethylsilyl)trifluoroacetamide?
The molecular weight of N,N-Bis(trimethylsilyl)trifluoroacetamide is 257.0879 g/mol.
What are the applications of N,N-Bis(trimethylsilyl)trifluoroacetamide?
N,N-Bis(trimethylsilyl)trifluoroacetamide is used in heterocycle construction in medicinal chemistry and agrochemical discovery, as well as pharmaceutical synthesis routes and API production. It commonly serves as a versatile building block for organic synthesis. Available from CoreyChem as both...
Where can I buy N,N-Bis(trimethylsilyl)trifluoroacetamide?
You can request a quote for N,N-Bis(trimethylsilyl)trifluoroacetamide directly from CoreyChem. Contact us or email [email protected] for pricing and availability.
Does CoreyChem offer custom synthesis for N,N-Bis(trimethylsilyl)trifluoroacetamide?
Yes, CoreyChem provides custom synthesis services for N,N-Bis(trimethylsilyl)trifluoroacetamide and related compounds. Contact us with your specific requirements including quantity, purity, and timeline.