N-methyl-N-(trimethylsilyl)trifluoroacetamide
TL;DR: N-methyl-N-(trimethylsilyl)trifluoroacetamide (CAS 24589-78-4) is a chemical compound with molecular formula C6H12F3NOSi and molecular weight 199.06403 g/mol, supplied by CoreyChem (Career Henan Chemical Co., Ltd.) with ISO-certified quality and global shipping.
2,2,2-trifluoro-N-methyl-N-trimethylsilylacetamide
Also Known As: MSTFA, N-Methyl-N-(trimethylsilyl)trifluoroacetamide, null, 2,2,2-Trifluoro-N-methyl-N-(trimethylsilyl)acetamide, 5-Decanol
Application Areas
Top 5 of 19 IPC patent classification(s) from the SureChEMBL global patent database.
Technical Specifications
| Molecular Formula | C6H12F3NOSi |
| Molecular Weight | 199.06403 g/mol |
| XLogP | 1.84 |
| Topological Polar Surface Area (TPSA) | 20.3 Ų |
| Hydrogen Bond Donors | 0 |
| Hydrogen Bond Acceptors | 4 |
| Rotatable Bonds | 1 |
| Exact Mass | 199.06403 Da |
| Heavy Atoms | 12 |
| Complexity | 184.0 |
| SMILES | CN(C(=O)C(F)(F)F)[Si](C)(C)C |
| InChIKey | MSPCIZMDDUQPGJ-UHFFFAOYSA-N |
Product Description
Applications: N-methyl-N-(trimethylsilyl)trifluoroacetamide is used in heterocycle construction in medicinal chemistry and agrochemical discovery, as well as pharmaceutical synthesis routes and API production. It commonly serves as a versatile building block for organic synthesis. Available from CoreyChem as both catalog item and custom-synthesis project (mg to ton scale), with full analytical documentation (COA, MSDS, HPLC, NMR, MS).
A heterocyclic building block supplied by CoreyChem, N-methyl-N-(trimethylsilyl)trifluoroacetamide (CAS 24589-78-4) has the molecular formula C6H12F3NOSi and a molecular weight of 199.06 g/mol. Synonyms include MSTFA and N-Methyl-N-(trimethylsilyl)trifluoroacetamide.
Custom synthesis and full analytical documentation (COA/MSDS) are available from CoreyChem. Request a quotation with your required quantity and purity for current lead time and pricing.
Chemical Property Profile of N-methyl-N-(trimethylsilyl)trifluoroacetamide
Property Insights of N-methyl-N-(trimethylsilyl)trifluoroacetamide
The XLogP value of 1.84 suggests moderate lipophilicity, balancing water solubility and membrane permeability for N-methyl-N-(trimethylsilyl)trifluoroacetamide. With a topological polar surface area (TPSA) of 20.3 Ų, N-methyl-N-(trimethylsilyl)trifluoroacetamide exhibits relatively low polarity, potentially indicating favorable cell membrane permeability. Following Lipinski's Rule of Five, N-methyl-N-(trimethylsilyl)trifluoroacetamide has 0 hydrogen bond donor(s) and 4 hydrogen bond acceptor(s), all within the drug-like range, suggesting favorable oral bioavailability potential.
Frequently Asked Questions
What is the CAS number of N-methyl-N-(trimethylsilyl)trifluoroacetamide?
The CAS number of N-methyl-N-(trimethylsilyl)trifluoroacetamide is 24589-78-4.
What is the molecular formula of N-methyl-N-(trimethylsilyl)trifluoroacetamide?
The molecular formula of N-methyl-N-(trimethylsilyl)trifluoroacetamide is C6H12F3NOSi.
What is the molecular weight of N-methyl-N-(trimethylsilyl)trifluoroacetamide?
The molecular weight of N-methyl-N-(trimethylsilyl)trifluoroacetamide is 199.06403 g/mol.
What are the applications of N-methyl-N-(trimethylsilyl)trifluoroacetamide?
N-methyl-N-(trimethylsilyl)trifluoroacetamide is used in heterocycle construction in medicinal chemistry and agrochemical discovery, as well as pharmaceutical synthesis routes and API production. It commonly serves as a versatile building block for organic synthesis. Available from CoreyChem as...
Where can I buy N-methyl-N-(trimethylsilyl)trifluoroacetamide?
You can request a quote for N-methyl-N-(trimethylsilyl)trifluoroacetamide directly from CoreyChem. Contact us or email [email protected] for pricing and availability.
Does CoreyChem offer custom synthesis for N-methyl-N-(trimethylsilyl)trifluoroacetamide?
Yes, CoreyChem provides custom synthesis services for N-methyl-N-(trimethylsilyl)trifluoroacetamide and related compounds. Contact us with your specific requirements including quantity, purity, and timeline.