Bis(trimethylsilyl)trifluoroacetamide
TL;DR: Bis(trimethylsilyl)trifluoroacetamide (CAS 25561-30-2) is a chemical compound with molecular formula C8H18F3NOSi2 and molecular weight 257.0879 g/mol, supplied by CoreyChem (Career Henan Chemical Co., Ltd.) with ISO-certified quality and global shipping.
trimethylsilyl 2,2,2-trifluoro-N-trimethylsilylethanimidate
Also Known As: BSTFA, N,O-Bis(trimethylsilyl)trifluoroacetamide, bstfa-tmcs, Bis(trimethylsilyl)trifluoroacetamide, Tirofiban Impurity 69
Application Areas
Top 5 of 2 IPC patent classification(s) from the SureChEMBL global patent database.
Technical Specifications
| Molecular Formula | C8H18F3NOSi2 |
| Molecular Weight | 257.0879 g/mol |
| XLogP | 3.63 |
| Topological Polar Surface Area (TPSA) | 21.6 Ų |
| Hydrogen Bond Donors | 0 |
| Hydrogen Bond Acceptors | 5 |
| Rotatable Bonds | 3 |
| Exact Mass | 257.0879 Da |
| Heavy Atoms | 15 |
| Complexity | 250.0 |
| Purity | ≥98.5% (excluding chlorotrimethylsilane, GC), 99% (excluding TMCS) |
| Boiling Point | 45.0 |
| Density | 0.97 |
| Refractive Index | n20/D 1.384 (lit.) |
| SMILES | C[Si](C)(C)N=C(C(F)(F)F)O[Si](C)(C)C |
| InChIKey | XCOBLONWWXQEBS-UHFFFAOYSA-N |
Product Description
Applications: Bis(trimethylsilyl)trifluoroacetamide is used in heterocycle construction in medicinal chemistry and agrochemical discovery, as well as analytical chemistry as a reagent, standard, or reference material. It commonly serves as a versatile building block for organic synthesis. Product profile: commercial lots are supplied at ≥98.5% (excluding chlorotrimethylsilane, GC), 99% (excluding TMCS). Available from CoreyChem as both catalog item and custom-synthesis project (mg to ton scale), with full analytical documentation (COA, MSDS, HPLC, NMR, MS).
Bis(trimethylsilyl)trifluoroacetamide is a heterocyclic building block identified by CAS number 25561-30-2 and the molecular formula C8H18F3NOSi2 and a molecular weight of 257.09 g/mol. Physically, the compound has a density of 0.97 g/cm³. Synonyms include BSTFA and N,O-Bis(trimethylsilyl)trifluoroacetamide.
Custom synthesis (mg to ton scale), HPLC/NMR/MS analytical support, and complete COA/MSDS documentation are available from CoreyChem. Request a quotation with your required quantity and purity for current lead time and pricing.
Safety Information
H225, H315, H319, H1594
Chemical Property Profile of Bis(trimethylsilyl)trifluoroacetamide
Property Insights of Bis(trimethylsilyl)trifluoroacetamide
The XLogP value of 3.63 indicates that Bis(trimethylsilyl)trifluoroacetamide is lipophilic (fat-soluble), which may influence its absorption, distribution, and formulation strategy. With a topological polar surface area (TPSA) of 21.6 Ų, Bis(trimethylsilyl)trifluoroacetamide exhibits relatively low polarity, potentially indicating favorable cell membrane permeability. Following Lipinski's Rule of Five, Bis(trimethylsilyl)trifluoroacetamide has 0 hydrogen bond donor(s) and 5 hydrogen bond acceptor(s), all within the drug-like range, suggesting favorable oral bioavailability potential.
Frequently Asked Questions
What is the CAS number of Bis(trimethylsilyl)trifluoroacetamide?
The CAS number of Bis(trimethylsilyl)trifluoroacetamide is 25561-30-2.
What is the molecular formula of Bis(trimethylsilyl)trifluoroacetamide?
The molecular formula of Bis(trimethylsilyl)trifluoroacetamide is C8H18F3NOSi2.
What is the molecular weight of Bis(trimethylsilyl)trifluoroacetamide?
The molecular weight of Bis(trimethylsilyl)trifluoroacetamide is 257.0879 g/mol.
What are the applications of Bis(trimethylsilyl)trifluoroacetamide?
Bis(trimethylsilyl)trifluoroacetamide is used in heterocycle construction in medicinal chemistry and agrochemical discovery, as well as analytical chemistry as a reagent, standard, or reference material. It commonly serves as a versatile building block for organic synthesis. Product profile:...
Where can I buy Bis(trimethylsilyl)trifluoroacetamide?
You can request a quote for Bis(trimethylsilyl)trifluoroacetamide directly from CoreyChem. Contact us or email [email protected] for pricing and availability.
Does CoreyChem offer custom synthesis for Bis(trimethylsilyl)trifluoroacetamide?
Yes, CoreyChem provides custom synthesis services for Bis(trimethylsilyl)trifluoroacetamide and related compounds. Contact us with your specific requirements including quantity, purity, and timeline.